眼用制剂致不良反应208例文献分析 - 中国药房.pdfVIP

眼用制剂致不良反应208例文献分析 ＊ # 马 勤 ，黄滔敏 （复旦大学附属眼耳鼻喉科医院药剂科，上海 200031） 中图分类号 R969.3 文献标志码 A 文章编号 1001-0408（2013）44-4192-04 DOI 10.6039/j.issn. 1001-0408.2013.44.20 摘 要 目的：探讨眼用制剂致不良反应（ADR ）的特点及一般规律，为临床合理用药提供参考。方法：检索1995年1月－2013年 6月国内医药期刊发表的文献，获得眼用制剂致ADR 文献137篇，合计208例患者，就其ADR 相关情况进行统计分析。结果：临床 上眼用制剂致ADR 以阿托品滴眼液、复方托吡卡胺滴眼液、氯霉素滴眼液、盐酸丁卡因滴眼液最为常见，妥布霉素地塞米松滴眼 液和噻吗洛尔滴眼液致ADR 也较多见；在儿童和老年人中发生率较高；多发生在给药后24h 内；其临床表现以过敏反应、变态反 应和心血管系统反应居多。结论：临床医师、药师应重视眼用制剂致ADR 的规律和特点，加强其合理使用和监测，确保用药安全。 关键词 眼用制剂；不良反应；文献；分析；合理用药 Adverse Drug Reactions Induced by Ophthalmic Preparations ：Literature Analysis of 208 Cases MA Qin ，HUANG Tao-min （Dept. of Pharmacy ，EyeEnt Hospital of Fudan University ，Shanghai 200031， China ） ABSTRACT OBJECTIVE ：To investigate the pattern and general characteristics of adverse drug reactions （ADRs ）induced by ophthalmic preparations ，and to provide reference for rational use of drugs in the clinic. METHODS ：208 cases of systematic ADRs induced by ophthalmic preparations in 137 literatures were collected from domestic medical journals during Jan. 1995－ Jun. 2013，and then ADR cases were analyzed statistically. RESULTS ：ADR were often caused by Atropine eye drops ，Compound tropicamide eye drops ，Chloramphenicol eye drops ，Tetracaine hydrochloride eye drops ，followed by Tobramycin and dexametha- sone eye drops and Timolol eye drops.The children and aged people occupied the highest proportion ；they often appeared 24h after medication. The main clinical manifestations of ADRs were allergic reaction ，anaphylaxis and cardiovascular system reaction. CON- CLUSIONS ：Clinical physicians and pharmacist should pay attention to the pattern and characteristics of ADRs induced by ophthal- mic preparations and strengthen ADR monitoring to ensure that the safety of drug use. KEY WORDS Ophthalmic preparation ；Adverse drug reactions ；Literature ；Analysis ；Rational drug use