肾气丸对肾阳虚小鼠血清T3、T4的影响.pdfVIP

四 川 中 医 2008年第26卷第5期 · 6 · Journal of Siehuan of Traditional Chine~Medicine Vo1．26．No．5，2008 肾气 丸对 肾 阳虚 小 鼠 血清 T3、T4的影 响 采 陈 辉 李 震2 陶汉华2 1．广州中医药大学 (广东广州510405) 2．山东中医药大学 (山东济南250014) 摘要：目的：探讨肾气丸对 “房事不节、劳倦过度”诱发的肾阳虚模型小鼠血清T3、T4水平的影响。方法：选 健康雄性昆明种小白鼠45只，随机分为对照组、房事不节+劳倦过度组 (模型组)和治疗组，每组各l5只。用强迫 小鼠游泳方法造成劳倦过度，同时以Colldege效应诱导雄性小鼠房事不节，建立肾阳虚小鼠模型，用肾气丸作为治疗 药物，观察各组血清T1、T4水平的变化。结果：肾阳虚组小鼠与正常对照组对比，血清T3、T4水平明显下降 (P 0．01)，治疗组小鼠与模型组相比，血清T3、T4水平明显升高 (P0．05)。结论：肾气丸能上调肾阳虚小鼠的血清T3、 L水平可能是其治疗肾阳虚证的机理之一。 关键词：肾气丸 房事不节 劳倦过度 肾阳虚 T3、T| 小鼠 中图分类号：R 285．67 文献标识码：A 文章编号：1000—3649(2008)05—0O06—02 Effects ofShengqi Pill O11 1r3 and T4 Level in Blood Serum ofKidney—Yang Deficiency Mice／Chen Hui。 Li Zhen Too ttan— hua ／／1．Guangz)wu University of Traditional Chinese Medicine(Guangz~u Guangdong 510405。China) 2．Shandong University of Trad／tiona／Ch／nese Med／c／ne(J／nan Shandong 250014。China) Abstract：Objective：To explore the effect of Shengqi Pill on T3 and T4 level in blood serum of Kidney—Yang deficiency mice induced by over fatigue and sexual overstrain． Methods：A total of 45 healey male mice were mn~mly divided into normal group。 over~figue plus sexual overstrain group(model group)and therapy group·with 15 mice in each group．Kidney—Yang deficiency model could be made by forcing male mice to swim and inducing sexual ove~ mn in male mice through Colldege effect．Shenqi Pills served as medication．瓢le changes of 33 and T4 level in blood serum in different grou ps were observed．Results：33 and T4 level in blood serum in model group were lower than those in normal group(P-0．01)。and higher than those in therapy group eP0．05)． Conclusion：11le up—regulation on T3 and T4 level in blood serum is possibly one of the mechanisms of Shenqi Pill in treating Kidney — Yang defici