伴强迫症状抑郁症患者甲状腺功能及体液免疫特征.docVIP

伴强迫症状抑郁症患者甲状腺功能及体液免疫特征【摘要】 目的探讨伴强迫症状抑郁症患者的内分泌及免疫的特征。 方法符合中国精神障碍分类与诊断标准第3版抑郁发作标准的住院患者96人,根据是否伴强迫症状分为伴强迫症状组(N=29)和不伴强迫症状组(N=67),采用放射免疫分析法检测两组患者的血清三碘甲状腺素原氨酸(T3),甲状腺素(T4),游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平,采用免疫透射比浊法检测两组患者的血清免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、补体3(C3)、补体4(C4)水平。 结果伴强迫症状组(15.*65±3.03)血清FT4高于无强迫症状组(14.65±1.51)( t =2.015, P =0.047),T3、T4、FT3、TSH的两组间差异无统计学意义( P 0.05);两组体液免疫各指标的差异均无统计学意义( P 0.05)。 结论伴强迫症状抑郁症患者可能存在甲状腺功能异常。 【关键词】 抑郁症;亚型;内分泌系统;免疫系统 ?? Features of thyroid function and humoral immunity status in patients with depressive disorder accompanied by obsessive?compulsive symptoms HONG Chun?xia,WANG Xiang?lan,HAN Zi?li,et al.Department of Infectious Disease,The Third Affiliated Hospital of Sun Yat?sen University,Guangzhou,Guangdong,Guangzhou 510630,China 【Abstract】 ObjectiveTo explore the characteristics of both thyroid function and humoral immunity status of patients with depression accompanied by obsessive?compulsive symptoms(DAOC). MethodsSerum concentrations of T3,T4,FT3,FT4 and TSH of patients with DAOC(N=29),and without obsessive?compulsive symptoms(DNOC,N=67)were detected by radio immunoassay method.Serum concentrations of IgG,IgA,IgM,C3,and C4 of patients in both two groups were detected by scatter velocity turbidimetry method.Group comparison was used to analyze the features of both thyroid function and humoral immunity status of patients with DAOC. ResultsPatients with DAOC(15.*65±3.03)had higher mean concentration of serum FT4 those with DNOC(14.65±1.51)( t =2.015, P =0.047),and group differences of concentrations of serum T3,T4,FT3,and TSH were not statistically significant( P 0.05).There were no significant differences of concentrations of serum IgA,IgG,IgM,C3,and C4 between patients with DAOC and DNOC( P 0.05). ConclusionPatients with depression accompanied by obsessive?compulsive symptoms may have abnormal thyroid functions. 【Key words】 Depressive disorder;Subtype;Endocrine system;Immune system ? 作者单位:51