内分泌腺来源血管内皮生长因子在多囊卵巢中表达及意义.docVIP

内分泌腺来源血管内皮生长因子在多囊卵巢中表达及意义??【摘要】 目的 研究内分泌腺来源的血管内皮生长因子(EG?VEGF)在多囊卵巢的表达，并与血管内皮生长因子(VEGF)的表达进行比较，探讨EG?VEGF在多囊卵巢综合征(PCOS)发病机制中的作用。方法 采用免疫组化SP法检测多囊卵巢及正常卵巢组织中EG?VEGF及VEGF的表达情况。结果 EG?VEGF在研究组中的表达水平显著高于对照组(P=0.001)。VEGF在研究组中的表达水平明显高于对照组(P=0.021)。研究组中EG?VEGF的表达水平高于VEGF的表达水平(P=0.036)，二者表达无相关性(P=0.327)。对照组中EG?VEGF的表达水平略高于VEGF的表达水平，但差异无统计学意义(P=0.655)，二者表达仍无相关性(P=0.928)。结论 EG?VEGF蛋白的过度表达促进多囊卵巢综合征患者的血管生成，与多囊卵巢综合征的发生相关。? 【关键词】 多囊卵巢综合征；内分泌腺来源的血管内皮生长因子；血管内皮生长因子；免疫组化 ??The expression and significance of endocrine gland?derived vascular endothelial growth factor in polycystic oraries WU Li?shu,REN Feng?yan,WANG Chun?xiao,et al. Department of Obstetrics and Gynecology,The People’s Hospital of Daqing HeiLongJiang，163316,China ? 【Abstract】 Objective To research the expression of EG?VEGF in polycystic ovaries and compare with VEGF,in order to explore the role of EG?VEGF in development and progression of PCOS. Methods The expression of EG?VEGF and VEGF in polycystic ovaries and normal ovarian tissues were detected by immunohistochemistry.Results The expression levels of EG?VEGF in the study group were significantly higher than those in the control group(P=0.001). The expression levels of VEGF in the study group were significantly higher than those in the control group(P=0.021). The expression levels of EG?VEGF in the study group were higher than that of VEGF(P=0.036),but there was no dependablity between the two factors(P=0.327). The expression levels of EG?VEGF in the control group were a little higher than that of VEGF,but there were no statistically significant(P=0.655),and there was no dependablity between the two factors(P=0.928). Conclusion Overexpression of EG?VEGFpromote angiogenesis of polycystic ovary syndrome and is associated with the progression of polycystic ovary syndrome. ? 【Key words】 Polycystic ovary syndrome; EG?VEGF；VEGF；Immunohistochemistry 多囊卵巢综合征（PCOS）是常见的育龄妇女内分泌疾病之一，以卵泡内膜及间质的增生和过度血管化为主要特征,发病率为6%~8%。多年来由于确切的发病机制不清，一直缺乏理想的治疗手段。目前研究表明，血管生成