汉防己甲素配合放疗治疗局部晚期及复发直肠癌临床探究.docVIP

汉防己甲素配合放疗治疗局部晚期及复发直肠癌临床探究[摘要] 目的探讨汉防己甲素(Tetrandrine,Tet)对局部晚期和复发直肠癌放疗增敏作用及其不良反应。方法回顾性分析2000年至2005年收治的局部晚期和复发直肠癌33例患者的临床资料，其中15例给予单纯放疗(放疗组),18例放疗的同时给予Tet(Tet组)。放疗采用15MVX线常规分割照射，病灶总量达60-66Gy/30~33F/6~7周。Tet组在照射第1天开始服用Tet，每次40mg，3次#8226;d-1，直至放疗结束。结果两组患者局部症状缓解率均为100%,症状缓解开始的中位时间Tet组较放疗组短，但差异无统计学意义(P0.05)。Tet组和放疗组便血和疼痛症状缓解持续的中位时间分别为15个月和8个月，具有统计学差异（P0.05)。结论Tet配合放疗，能有效延长局部晚期和复发直肠癌局部症状缓解持续时间，生存率有提高趋势，可能是一种理想的放射增敏剂。? [关键词] 汉防己甲素；放射治疗；直肠癌? [中图分类号] R735.37；R730.55 [文献标识码] A [文章编号] 1671-7562(2008)02-0097-04?? Radiotherapy with Tetrandrine for locally advanced? and recurrent rectal cancer?? CAO Yuan-dong?1,SUN Xin-chen ?1,CHENG Hong-yan?1,YU Da-hai?2,? GE Xiao-lin?1,LI Yi-kun?1,XUE You-hua?1,LIN Qian?1,MA Chun-yang?1 (1.Department of Oncology,Zhongda Hospital，Southeast University,Nanjing 210009,China; 2.Department of ?Radiotherapy,Xuzhou Hospital Affiliated to Medical College of Southeast University,Xuzhou 221009,China)?? Abstract:Objective To study the effect of radiotherapy combined with Tetrandrine(Tet)in the treatment of locally advanced and recurrent rectal cancer.Methods The data of 33 cases of locally advanced and recurrent rectal cancer from 2000 to 2005 were analysed retrospectively,of which 15 patients received radiotherapy(radiotherapy group),18 cases received radiotherapy combined with Tet(Tet group).All patients were treated with conventional radiotherapy by 15MVX ray to a total dose of 60-66Gy in 6-7 weeks for the respectable disease.During radiotherapy of the Tet group ,all the patients took Tet 40mg every time and three times per day.ResultsLocal symptom remission rate was 100% for the two groups.Symptoms remission beginning time of the Tet group was shorter than the radiotherapy group，but had no statistical difference(P0.05).Hematochezia and pain relief sustained median time of the Tet group and the radiotherapy group were 15 months and 8 months,and there was a significant difference between the two groups(P0.05).1,2,3-year survival