苏北地区食管癌发病影响因素Logistic回归研究.docVIP

苏北地区食管癌发病影响因素Logistic回归研究【摘要】 目的 探讨苏北地区居民生物因素、饮食行为等各种影响因素与食管癌发生的关系。方法 对近两年苏北地区食管癌患者进行1∶1 配对病例-对照研究,对154例食管癌病例及对照进行问卷调查,采用条件Logistic 回归对所获资料饮食因素、生活状况及习惯、身体状况等因素进行筛选。结果 盐腌食品、辛辣食物、吃早餐情况、植物油消耗量、食盐消耗量、食管炎史、食管肿瘤家族史、吞咽困难、经常生气、每日吸烟数量、吸烟年数等与食管癌呈显著正相关,可能是其危险因素;而医保制度、家庭月收入总额、摄入奶制品、吃鸡蛋与食管癌呈显著负相关,提示为保护因素。结论 食管癌是生物因素、饮食生活习惯、社会因素等对具有不同遗传体质的个体长期反复作用的结果,宜采取以一级预防为重点的综合性防治措施。 【关键词】 食管癌;影响因素;Logistic分析 Logistic regression analysis on the influence factors of esophageal neoplasm in north area of Jiangsu. XU Ji-cheng,LIU Cui-hong,ZHOU Feng-juan,et al. Xuzhou Nedical Unirersity of Public Health,Xuzhou 221002,China 【Abstract】 Objective To explore the risk factors of esophageal neoplasm in north area of Jiangsu province.Methods Using standardized questionnaire, 1:1 matched case-control study was performed on 154 cases of EC and 154 controls for age, gender, and residence matched. Conditional logistic regression was used to analyze and screen out the risk factors for EC such as food, behavior, family history and environmental factors.Results The risk factors of EC included the family history of EC, high salt diet ,eating spicy foods , years of smoking , difficulty in swallowing, often angry etc. The protective factors was the medical insurance system , the total family income, milk drinking etc. Conclusion The high incidence of EC is not only related with food, living habits and community factors but also related with the family history of EC. So if we want to reduce the incidence rate of EC , we should use general methods and the emphases is primary prevention. 【Key words】 Esophageal neoplasm; Influence factor; Logistic analysis 食管癌是人类常见的恶性肿瘤之一,我国也是食管癌的高发地区,其发病率和死亡率均居世界前列。目前国内外在食管癌病因学研究方向虽然有一些进展,但对其发病危险因素认识不一。多数学者均认为食管癌是一种多病因联合作用产生的疾病,生物因素、饮食因素、生活方式和习惯、精神因素、环境因素、家族史等都与食管癌的发生可能有关[1]。本研究首次选取近两年苏北地区部分食管癌患者进行病例对照研究,旨在探讨本地区食管癌的发病影响因素,合理制定本地区食管癌的综合防治措施。 1 资料与方法 1.1 一般资料 研究对象病例组:选择近两年在徐州市各大医院就诊经病理确诊为食管癌的患者,共154例。对照组:按1:1配对,选择与病例组居住同一乡镇,无血缘关系,同民族、同性别、年龄相差5岁以内的同期住院的非肿瘤患者,如