视网膜静脉栓塞治疗中使用阿魏酸钠临床探究.docVIP

视网膜静脉栓塞治疗中使用阿魏酸钠临床探究【摘要】 目的 探讨阿魏酸钠注射液治疗视网膜静脉栓塞的临床效果。方法 80例(80只眼)视网膜静脉栓塞患者, 随机分成治疗组和对照组各40 例。对照组给予常规治疗, 治疗组给予阿魏酸钠注射液300 mg／d 静脉滴注, 14 d 为1个疗程。测定治疗前后视力、视网膜中央静脉血流速度、视网膜中央动脉平均收缩期峰值血流速度。结果 应用阿魏酸钠治疗后, 视力明显改善, 视网膜中央静脉血流速度和收缩期峰值血流速度显著提高, 与对照组治疗后相比均有显著性差异, 疗效优于对照组。结论 阿魏酸钠治疗视网膜静脉栓塞疗效显著。? 【关键词】视网膜静脉栓塞; 阿魏酸钠; 视功能?? Clincal research of sodium ferulate on retinal vein occlusion DU Ling-zhi,LIU Jing-jing.Department of Pharmacy,the Second Peoples Hospital of Henan,Jiaozuo 454150, China ? 【Abstract】 Objective To explore the effect of sodium ferulate on retinal vein occlusion (RVO). Methods Eighty patients (80 eyes) of RVO randomly divided into two groups. 40 patients (40 eyes) in treatment group were cured with Sodium Ferulate 300 mg／d intravenously; 40 patients (40 eyes) in control group were cured with routine treatment. Before and after 14 days therapy, the visual acuity and as central retinal rein velocity (CRV ) as well mean peak systolic velocity (PSV )of central retinal artery were exam in ized on each patient. Results After therapy, the visual acuity and CRV as well as PSV in both groups were improved significantly than those of pretreatment. The effective rate of Sodium Ferulate in treatment group were superior to those in control group. Conclusion odium ferulate is an effective agent on treating RVO.? 【Key words】Retinal vein occlusion; Sodium ferulate;Visual acuity 视网膜静脉栓塞是血液流变学、血流动力学改变，以及眼压和眼局部受压等多种因素综合作用的结果，是临床上常见的眼底血管性疾病。它常突然发病, 若得不到及时有效的治疗, 视功能损害极为严重。本组资料利用彩色多普勒成像技术和视力, 评价阿魏酸钠[1]对视网膜静脉栓塞的疗效, 并探讨其可能的作用机制。? 1 资料与方法? 1．1 一般资料 2003 年8月至2007年2月在本院眼科确诊的视网膜静脉栓塞患者80例(80只眼),男48例(48只眼),女32例(32只眼),年龄40～78岁,平均(58．2±11．6)岁,病程不超过15 d。排除视网膜脱离、增生性视网膜病变、糖尿病、缺血性视神经病变及其他血液系统疾病。按入院先后随机分为对照组和治疗组各40例(40只眼)。两组间性别、年龄、治疗前病程和视力差异无显著性。? 1．2 治疗方法 所有患者均给予基础治疗:口服肌苷，地巴唑、烟酸,维生素B1、B12，止血药，促吸收药。对照组给予川穹嗪注射液160 mg加入低分子右旋糖酐250 ml中静脉滴注;治疗组给予阿魏酸钠注射液300 mg/d加入5%葡萄糖液250 ml中静脉滴注,14 d为1个疗程。? 1．3 观察项目 治疗前后检查视力。利用彩色多普勒成像技术(CDI)测量视网膜中央静脉血流速度(central retinal rein velocity,CRV)和视网膜中央