雷贝拉唑联合左氧氟沙星及阿莫西林治疗消化性溃疡疗效.docVIP

雷贝拉唑联合左氧氟沙星及阿莫西林治疗消化性溃疡疗效【摘要】 目的 评价雷贝拉唑联合左氧氟沙星与阿莫西林治疗消化性溃疡(PU)的疗效。方法 将120例幽门螺杆菌(Hp)阳性的PU患者随机分为对照组及观察组，每组各60例。观察组给予雷贝拉唑10 mg、左氧氟沙星200 mg、阿莫西林1000 mg，均为2次/d口服。对照组给予奥美拉唑20 mg、克拉霉素500 mg、阿莫西林1000 mg，均为2次/d口服。疗程均为2周。停药后4周复查胃镜及Hp检测。结果 观察组总有效率95%，对照组总有效率80%；观察组Hp根除率为90％，对照组为70%。结论 雷贝拉唑联合左氧氟沙星与阿莫西林治疗Hp阳性的PU疗效好，是理想方法之一。? 【关键词】 雷贝拉唑；左氧氟沙星；阿莫西林；克拉霉素；消化性溃疡；幽门螺杆菌 ?? The therapeutic effect of triple combined regimen of Rabeprazole and Levofloxacin, Amoxicill therapy for peptic ulcer WANG Zhao?xuan. Department of Digestive,The First Poeople’s Hospital of Jining,Shandong 272111,China ? 【Abstract】 Objective To evaluate the therapeutic effect of triple therapy of Rabeprazole and Levofloxacin，Amoxicill combined for peptic ulcer.Methods 120 patients with helicobacter pylori(Hp)infection suffered from peptic ulcer were randomly divided into observation groupand control group,60 cases in each group.Observation group were administrated Rabeprazole(10 mg，twice a day)，Levofloxacin(200 mg，twice a day)and Amoxicill (1000 mg，twice a day)for two weeks.Control group were treated with Omeprazole(20 mg，twice a day)，Amoxicillin(500 mg，twice a day)and Clarithromycin(200 mg，twice a day)for two weeks.Four weeks later, the Hp eradication rate and the total effective rate were observed. Results After the treatment the total effective rate of the observation group was 95%, while that of the control group was 80%,the dfferences were statistically significant (P0.05)，具有可比性。? 1.2 治疗方法 观察组给予雷贝拉唑10 mg、左氧氟沙星200 mg、阿莫西林1000 mg，均为2次/d口服。对照组给予奥美拉唑20 mg、克拉霉素500 mg、阿莫西林1000 mg，均为2次/d口服。疗程均为2周。两组患者在治疗期间禁用其他药物，禁食刺激性食物，治疗前后查肝肾功能、血、尿常规及对Hp检测。停药后4周复查胃镜观察溃疡愈合情况及进行Hp检测观察转阴率，进而评价疗效? 1.3 检测Hp方法 治疗前及治疗后停药至少4周，通过胃镜确诊及检查溃疡是否愈合的同时取活检做??14?C?呼气试验和(或)组织学检查，确诊时阳性者为Hp感染，检查溃疡是否愈合时阴性表示根除。? 1.4 疗效评价 主要从两个方面评价：①主要从溃疡愈合情况、临床症状及胃镜所见，从治愈、好转及无效三个标准评价，总有效率=治愈率+好转率。②Hp根除情况。? 1.4.1 治愈 临床症状及体征消失，胃镜示溃疡愈合；好转：临床症状及体征较治疗前好转，胃镜示溃疡愈合面积50%；无效：临床症状及体征较治疗前未见好转、甚至加重，胃镜示溃疡愈合面积 1.5 统计学方法 使用SPSS 15