高敏C反应蛋白及代谢综合征患者关系探究.docVIP

高敏C反应蛋白及代谢综合征患者关系探究【摘要】 目的 探索代谢综合征患者血清高敏C反应蛋白（hs-CRP）与冠状动脉病变严重程度的关系，以及hs-CRP与严重心脏事件（MACE）发生率之间的关系。方法 对125例代谢综合征患者，测定其hs-CRP值，并行冠状动脉造影，平均随访12个月，观察其MACE发生率，以及hs-CRP与MACE发生的相关性，进行统计学分析。结果 随访期间，有15例发生MACE，发生者的hs-CRP均值显著高于未发生者（7．62 μg/ml 1．45 μg/ml，P0．01）。随着hs-CRP水平的升高，冠状动脉病变的严重程度显著加重，MACE发生率明显增加。在COX回归分析中，位于第四个四分位数的患者与第一个相比，MACE发生的危险比为2．04（95％ CI∶1．67~2．52, P0．01）。结论 hs-CRP可作为预测代谢综合征患者冠状动脉病变的严重程度及MACE发生率的强有力的指标。 【关键词】 高敏C反应蛋白； 代谢综合征； 冠状动脉造影； 预后 Prognostic value of serum high-sensitivity C-reactive protein in patients with metabolic syndrome ZHANG Qiang，LIANG Feng-yan，LIU Zhong-hua，et al.Department.of Cardiology, Weihai Hospital, Medical College of Qingdao University, Weihai, Shangdong, 264200，China 【Abstract】 Objective To observe the relationship between serum high-sensitivity C-reactive protein(hs-CRP) level and cardiovascular events in patients with metabolic syndrome. Methodshs-CRP was measured at baseline serum samples from 125 patients refered for angiography. The rate of cardiovascular events was determined after a average follow-up of 12 months. Statistical analysis was done. Results In the follow-up period, 15 patients had suffered with MACE, the average hs-CRP level was significantly lower among patients who survived than among those(7．62 μg/ml vs 1．45 μg/ml，P0．01). The hs-CRP level was linked to the severity of coronary artery lesion. In COX regression model, the hazard ratio of MACE for patients with hs-CRP level in the fourth quartile compared with those patients in the first quartile was 2.04(95％ CI:1．67~2．52, P0．01). Conclusion hs-CRP is a powerful marker of the cardiac risk in patients with metabolic syndrome, and hs-CRP is a marker to predict the severity of coronary artery lesion. 【Key words】 High-sensitivity C-reactive protein(hs-CRP); Metabolic syndrome; Coronary angiography; Prognosis 代谢综合征是指包括肥胖、脂质代谢异常、高血压及血糖异常在内的一组临床综合征[１]，它是导致冠心病的独立危险因素[2-3]。代谢综合征患者血浆中的高敏C反应蛋白（high-sensitivity C-reactive protein, hs-CRP）水平显著增高已有报道[4]，但关于代谢综合征患者，hs-C