蒙成药嘎日迪-5对小鼠与大鼠行为、镇痛作用影响.docVIP

蒙成药嘎日迪-5对小鼠和大鼠行为、镇痛作用的影响 王欢 王秀兰 吴龙堂 （内蒙古民族大学蒙医药学院，通辽，028041） （国家民委—教育部—重点实验室蒙药药理毒理实验室） 摘 要：目的：观察蒙成药嘎日迪-5对小鼠和大鼠行为、镇痛作用的影响。方法：通过小鼠催眠试验、降低组织MDA水平实验观察对行为的影响；通过小鼠扭体实验、小鼠热板法实验、大鼠尾尖部压痛实验观察镇痛作用。结果：通过催眠实验蒙成药嘎日迪-5高、中剂量组对小鼠具有明显的催眠作用（分别P0.01和P0.05），通过降低组织MDA水平实验蒙成药嘎日迪-5高、中、低剂量组对肝脏有明显降低MDA水平的作用（P0.001）；通过小鼠扭体实验蒙成药嘎日迪-5高、中、低剂量组对小鼠醋酸引起的扭体次数有明显的降低作用（P0.01）；通过小鼠热板法实验蒙成药嘎日迪-5高剂量组在90min之内对小鼠添后足时间有明显的延长作用（p0.05）表明有明显的镇痛作用，90min后对小鼠添后足时间没有明显的延长 (p0.05)；通过大鼠尾尖部压痛实验蒙成药嘎日迪-5中剂量组与正常组比较对大鼠尾尖部增加痛阈值作用明显（P0.05）、高剂量组与正常组比较增加痛阈值作用非常明显（P0.01）。结论：初步研究证明蒙成药嘎日迪-5对小鼠和大鼠行为有明显的抑制，疼痛反应也有明显的抑制作用。 关键词：蒙药嘎日迪-5；小鼠、大鼠；行为和镇痛作用； Abstract Objective: To observe the Mongolian Medicine Ga Ri Di - 5 on the behavior and analgesic effects. Methods: Experimental Hypnosis, anti-aging experimental observation of the behavior of through the writhing experimental mice, the mice hot plate experiment, rats tail tip tenderness experimental observation of the analgesic effect. Results: Experimental Hypnosis, Mongolian Medicine Ga Ri Di - 5 high, medium-dose group of mice with the obvious role of hypnosis (P 0.01 and P 0.05), Mongolian medicine through the anti-aging experiments on Ga Ri Di - 5 high, medium and low Dose of the liver and kidneys have significantly decreased the level of the role of MDA (P 0.001); through the experimental mice writhing on the Mongolian Medicine Ga Ri Di - 5 high, medium and low-dose group of mice caused acetate The writhing significantly reduce the number of (P 0.01); through the experimental mice hot plate, Mongolian Medicine Ga Ri Di - 5 high-dose group within 90 min in a significant extension of full time after Tim mice (p 0.05) Indicated that a significant analgesic effect, 90 min after the extension of no obvious enough time after the mice Tim (p 0.05); through the tip of the tail of the tenderness of the Mongolian Medicine Ga Ri Di - 5 in the dose group and the normal group of large The tip of the rat tail pain threshold has increased significantly (P 0.05), high-dose group and the no