脆性哮喘（Brittle asthma）.doc

脆性哮喘（Brittle asthma） As early as the early 1970s, foreign scholars indicated that asthma may have different types according to the differences in the expiratory peaks of asthmatic patients. Especially PEF fall in the morning or day changes in patients with asthma who are very volatile, often performance deterioration, and even death, prompt PEF variation characteristics and condition changes and prognosis in patients with asthma have a close relationship. The concept of brittle asthma is proposed. Explain various brittle asthma in the past, the British thoracic society published in his 1993 guide to the treatment of asthma in the explanation for the sudden onset, severe life-threatening asthma, and PEF variation is considered to be main lethal factors significantly. Some people think that brittle asthma is often referred to as persistent, refractory asthma. Ayres heald units such as all kinds of views presents brittle asthma after PEF curve, its characteristic is: falls in the morning and have a clear graphics, the day the size of the variation of main to day rather than by way of mutation as the judgment standard. Adults now brittle asthma mainly according to its clinical features is defined as the brittle asthma type I and type II brittle asthma two types, the two are different etiology, clinical characteristics and treatment measures, including the former accounts for most. Type I brittle asthma: the clinical characteristics of the regular medication, the positive including high-dose inhaled corticosteroids (such as inhaled beclomethasone propionate or budesonide daily sooug 1 or over 750 ug fluticasone or other the same amount of glucocorticoids), plenty of systemic use of glucocorticoid and repeated inhaled bronchodilator (general use B2 receptor agonist atomization inhalation), asthma symptoms still break out repeatedly, PEF daily variation rate of the continuous variation significantly. The specific diagnostic criteria were: 1. Continuous observation of more