教材分析 MIT机电工程与计算机科学系【本科生课程】6.047.计算生物学，基因组，网络，演化.Computational.Biology.Genomes,.Networks,.Evolution[www.ed2kers.com].pdfVIP

Computational Biology: Genomes, Networks, Evolution As taught in: Fall 2008 Pictographic representation of the challenges in computational biology. (Image by Prof. Manolis Kellis.) Instructors: Prof. Manolis Kellis Prof. James Galagan MIT Course Number: 6.047 / 6.878 Level: Undergraduate / Graduate Course Description This course focuses on the algorithmic and machine learning foundations of computational biology, combining theory with practice. We study the principles of algorithm design for biological datasets, and analyze influential problems and techniques. We use these to analyze real datasets from large-scale studies in genomics and proteomics. The topics covered include:  Genomes: biological sequence analysis, hidden Markov models, gene finding, RNA folding, sequence alignment, genome assembly  Networks: gene expression analysis, regulatory motifs, graph algorithms, scale-free networks, network motifs, network evolution  Evolution: comparative genomics, phylogenetics, genome duplication, genome rearrangements, evolutionary theory, rapid evolution Syllabus Course Meeting Times Lectures: 2 sessions / week, 1.5 hours / session Recitations: 1 session / week, 1 hour / session Course Description This course focuses on the algorithmic and machine learning foundations of computational biology, combining theory with practice. We study the principles of algorithm design for biological datasets, and analyze influential problems and techniques. We use these to analyze real datasets from large-scale studies in genomics and proteomics. The topics covered include:  Genomes: biological sequence analysis, hidden Markov models, gene finding, RNA folding, sequence alignment, genome assembly  Networks: gene expression analysis, regulatory motifs, graph algorithms,