生物信息学讲课一-20060908.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * SARS 病毒3C-like proteinase的同源模建 以SARS基因组ORF1ab及ORF1a编码的氨基酸序列通过Swiss-Model进行三级结构预测，得到的三级结构文件完全相同，肽链长度为301个残基。 模建所用得模板PDB的id号为1lvo,该蛋白与SARS的 Identities = 134/306 43%, Positives = 60%。 ????? ?????????????????????????????????? ??????????????? ?????????????????????????????????????????????????????? 人类有多少基因 2万—20万 28,000±4,000 Cell 106, 413-415, August 24, 2001 3万—4万 到目前为止已定位在染色体上的基因数目有14015个 (见/LocusLink/statistics.html); 谢谢大家 Ensembl Genome Browser Source: * * * * * * * * * * * * * * * * * * * * * * * * * * A Draft Sequence of the Rice Genome (Oryza sativa L.?ssp. indica) Jun Yu,1,2,3,4* Songnian Hu,1* Jun Wang,1,2,5* Gane Ka-Shu Wong,1,,24*……… Science 2002 296: 79-92 Rice is the most important crop for human consumption, providing staple food for more than half the worlds population. The euchromatic portion of the rice genome is estimated to be 430 Mb in size (1-3), which is the smallest of the cereal crops. It is 3.7?times larger than that of A.?thaliana (4-6), and 6.7?times smaller than that of the human (7, 8). The well-established protocols for high-efficiency genetic transformation, widespread availability of high-density genetic and physical maps (9, 10), and high degrees of synteny among cereal genomes (11-15) combine to make rice a unique organism for studying the physiology, developmental biology, genetics, and evolution of plants. The International Rice Genome Sequencing Project (IRGSP) (16) has already delivered a substantial amount of sequence for the japonica (Nipponbare) subspecies, in bacterial artificial chromosome (BAC) and P1-derived artificial chromosome (PAC)-sized contigs. Working independently, Monsanto and Syngenta (17, 18) established proprietary working drafts for japonica, in April 2000?and F