早期加载对即刻种植体骨界面形成的影响 - 第三军医大学学报.doc

即刻种植即刻加载对骨结合界面形成的影响 吴 丹，王 璐，徐 凌，付 钢，游 涛 （400016重庆，重庆医科大学附属口腔医院修复科） [摘要] 目的 研究即刻载荷条件下即刻种植体的种植体骨结合界面形成的状况。方法 选用4只健康成年雄性Beagle犬，分别拔除其双侧下颌第3、第4前磨牙，并在其相应的拔牙窝位点即刻植入直径4.1mm，长度10.0mm奥齿泰（OSSTEM）SSⅡ系统种植体各1颗，术后24h采用自行研制的种植体专用垂直加载仪对种植体进行垂直加载，依据加载力值的不同分为：载荷大小5、10、15N组和不加载的对照组，各加载组每天以2Hz的频率加载15min，连续加载8周；加载0d及第1、2、3、4、5、6、7、8周后分别拍摄术区种植体的X线片，并测量记录种植体垂直向骨吸收量（VBL）。加载第4、8周后各处死2只Beagle犬，制作含种植体的骨组织切片，光镜下观察其组织结构并对新生骨进行定量分析。结果 (1)4周后加载5、10、15N组和对照组的VBL均值分别为0.39、0.30、0.31、0.26mm，加载组和对照组之间有统计学差异(P＜0.05)。8周后加载5、10、15N组和对照组的VBL均值分别为0.47、0.42、0.50、0.46mm，不同加载组以及加载组和对照组之间均无统计学差异(P＞0.05)。（2）硬组织切片显示4周末加载组种植骨界面的成骨量优于对照组，8周末加载组和对照组种植骨界面的成骨量和质相当。 结论 在本实验条件下，即刻垂直载荷并不阻碍即刻种植体骨性结合界面形成过程，且早期可能有一定的促进作用。 [关键词] 即刻种植；即刻载荷；骨结合界面 [中图法分类号] [文献标志码] A Influence of the immediate loading on the immediate implant to the formation of the implant-bone interface Wu Dan,Wang Lu,Xu Lin,You Tao,Fu Gang (Department of Prosthodontics,Affiliated Stomatology Hospital,Chongqing Medical University,Chongqing,400016,China) [Abstract] Objective To investigate the effect of immediate loading on the immediate implant-bone interface. Methods Choose 4 Beagle dogs, male .The bilateral mandibular third, foured premolar were extracted and implanted OSSTEM implant 4 immediately in each dog after 1 hour, total 16 implants. The vertical immediate loading by device was used on immediate implants after 4hours.The vertical loss (VBL) and osseointegration were detected by X-ray after 0day 1,2,3,4,5,6,7,8weeks.Half of dogs were put to death after 4weeks ,and other half were put to death after 8week, and made to hard tissue section. Results The VBL average of the groups with 5,10,15N loading was 0.39,0.30,0.31mm, the control group VBL average of 0.26mm after 4 weeks. two groups of comparisons exist statistical differences（P0.05）. The VBL average of the groups with 5,10,15N loading was 0.47,0.42,0.50mm, the control group VBL average of 0.46mm after 8 weeks, two groups of comparisons does not exist between statisti