博来霉素联合白细胞介素-2治疗恶性胸腔积液探究.docVIP

博来霉素联合白细胞介素-2治疗恶性胸腔积液探究摘要: 目的:观察博来霉素联合白介素-2胸腔灌注与单用顺铂治疗恶性胸腔积液的有效 性和安全性。方法:56例恶性胸腔积液患者的治疗用博来霉素联合白介素-2(A组)30例,单 用顺 铂(B组)26例。用一次性中心静脉导管行胸腔置管和闭式引流胸液,A组胸腔给药:博来霉素 45~60 mg+白介素-2(IL-2)100万U+注射用生理盐水50ml胸腔内注射;B组胸腔给药:顺铂 6 0mg/m2+生理盐水50ml。结果:A组#65380;B组治疗总有效率分别为88.67%和57.7%,差异有统计 学 意义(P0.05)。结论:胸腔闭式引流后灌注博来霉素联合白细胞介素-2治疗恶 性胸腔积液的疗效优于单用顺铂组,且毒副反应轻微。 关键词:博来霉素;白细胞介素-2;顺铂;恶性胸腔积液 中图分类号: R730.5 文献标识码: A 文章编号: 1008-2409(2009)05-0835-03 The application of bleomycin combined with Interleukin-2 in the treatment of ma lignant pleural effusion/HHANG Xian-shi,LU Yao-zhen,NONG Xian-sheng∥The Minzu Hospital of Guangxi, Nanning 530001, China Abstract:Objective: To evaluate the efficacy and safety of bleomycin combinedwith Interleukin-2 and single cis-diaminodichroplatin for m alignant pleural e ff usion. Methods:56 individuals of m alignant pleural effusion were divided into t w o groups:bleomycin combined with Interleukin-2 group(A group)including 30 i n dividuals;single cis-diaminodichroplatin group(B group) including 26 indiv i duals.M alignant pleural effusions were excreted cleanly from indwelling chest tu be.A group was injected by thorax with 40~60mg of bleomycin and 1000000 unitsof Interleukin-2, B group was injected with 60~80mg cis-diaminodichroplatin.R es ults: The total efficiency of A group and B group were 88.67% and 57.7%, therewassignificant difference(P0.05). Conclusion: Bleomyc in combined with Interleukin-2 were efficient and safety in the treatment of pa tients with mass m alignant pleural effusions.It deserves further applications. Key words:bleomycin; Interleukin-2; cis-diaminodichroplatin; m aligna nt pleural effusions 恶性胸腔积液是恶性肿瘤胸膜转移或原发于胸膜的恶性肿瘤所致,为恶性肿瘤常见并发症之 一。据统计24%~50%的渗出性胸腔积液源于恶性病变,50%的癌症转移患者最终发生恶性胸腔 积液[1]。大量胸水会严重影响患者的呼吸#65380;循环功能以及生存情况。经化学治疗 效果好的肿瘤类型,通过全身治疗即有可能控制胸腔积液,但多数病例不能达到满意的疗效 。 故长期以来,胸腔内局部给药为治疗胸腔积液的常见手段。我科对30例恶性胸腔积液的患者 采用中心静脉导管行腔内持续引流,并在胸腔内注入博来霉素 +白细胞介素-2(IL-2)治疗 ,取得了良好的疗效,现报告如下。 1 资料和方法 1.1 一般资料 2006年6月至2009年3月我科共收治晚期恶性胸腔积液患者56例,其中男27例