坎地沙坦联合络活喜治疗老年原发性高血压临床效果观察.doc

坎地沙坦联合络活喜治疗老年原发性高血压临床效果观察[摘要]目的 观察坎地沙坦联合络活喜治疗老年原发性高血压的临床效果，探讨治疗老年性高血压的最佳治疗方案方法 选择确诊为老年原发性高血压患者180例，根据自愿原则，分为A、B、C三组，A组56例采用络活喜治疗，B组58例采用坎地沙坦治疗，C组66例采用坎地沙坦联合络活喜治疗，治疗6周后比较三组患者的临床疗效；治疗前后SBP、DBP、心率及其差值；用药后的不良反应情况。结果 联合用药效果好于单一用药效果，在临床疗效、治疗前后SBP和DBP差值方面比较，差异有统计学意义（P＜0.05）。在治疗前后心率差值、用药后不良反应方面比较，无显著性差异（P＞0.05）。 结论 坎地沙坦联合络活喜治疗老年原发性高血压是安全有效的，应作为临床药物治疗的首选方案。 [关键词]坎地沙坦；络活喜；老年；原发性高血压 [中图分类号]R544.1[文献标识码] B [文章编号]1673-9701（2011）19-69-03 The Clinical Effects of Candesartan Combined with Norvasc in Treatment of Senile Essential Hypertension GU Feng General Department,Beijimg Municipal Dongcheng District Chaoyangmen Hospital, Beijing100010，China [Abstract] ObjectiveTo observe the clinical effects of Candesartan combined with Norvasc in treatment of Senile essential hypertension and discuss the best treatment method in senile essential hypertension. MethodsCollect 180 elder patients with essential hypertension, 56 patients were divided into A group with Norvasc treatment;58 patients were divided into B group with Candesartan treatment; 66 patients were divided into C group with two drugs treatment, then compare clinical effect after 6 weeks; SBP, DBP and heart rate changes;adverse reactions after treatment. Results Combination group was better than single agent group in clinical effect ,SBP and DBP changes,with there was a significant difference（P＜0.05）. There was no significant statistical significance was found（P＞0.05）in heart rate changes and adverse reactions after treatment. ConclusionCandesartan combined with Norvasc was safe and effective in treatment of senile essential hypertension,it should be the preferred options in treatment of senile essential hypertension. [Key words] Candesartan; Norvasc; Senile; Essential hypertension 原发性高血压是指体循环动脉压增高，可使收缩压或舒张压高于正常或两者均高。其本身可引起一系列症状，并降低患者生活、工作质量，重者甚至可威胁生命，长期高血压可影响重要脏器尤其是心、脑、肾的功能，最终导致脏器功能衰竭[1～3]。目前，我国是全世界老龄人口最多的国家之一，同时也是全世界老龄化速度最快的国家[4]。老年原发性高血压发病机制复杂，药物不仅可降低血压而且减少因高血压所致的病死率和自残率[5]。相关研究表明，联合应用不同种类的抗高血压药物，优于单用一种