外周血CD4+CD25+CD127-调节性T细胞在过敏性紫癜中表达及意义.doc

外周血CD4+CD25+CD127-调节性T细胞在过敏性紫癜中表达及意义[摘要] 目的 探讨外周血CD4+CD25+CD127+调节性T细胞在HSP患儿治疗前和治疗后的表达及其临床意义。 方法 选取HSP患儿41例作为观察组，选取健康儿童41例作为对照组，检测对照组儿童及观察组患儿治疗前后的CD4+CD25+CD127+值。 结果 （1）治疗前与对照组比较，CD4+CD25+CD127+明显降低（P ＜ 0.05）；（2）与治疗前比较，观察组患儿的CD4+CD25+CD127+值在治疗后明显升高（P ＜ 0.05）；（3）与对照组比较，观察组患儿治疗后CD4+CD25+CD127+值差异无显著性（P ＞0 .05）。 结论 外周血CD4+CD25+CD127+值在HSP患儿治疗前显著降低，给予有效的治疗后其值显著升高，可能在HSP的发生发展过程中调节性T细胞进行了参与。而对于HSP患儿对疾病的有效预测，可以对其CD4+CD25+CD127+值进行测定。 [关键词] 过敏性紫癜；外周血CD4+CD25+CD127-；调节性T细胞 [中图分类号] R725.5 [文献标识码] B [文章编号] 1673-9701（2012）03-0092-02 Expression and significance of peripheral blood CD4 + CD25 + CD127-regulatory T cells of children with Henoch-Schonlein purpura LI Yi HE Chaoqi ZHAO Yuan Department of Laboratory, Xiaoshan District the First Hospital Affiliated of Hangzhou Normal University Hospital, Hangzhou 311201, China [Abstract] Objective To explore the level of CD4+CD25+CD127+regulatory T cells in children with Henoch-Schonlein purpura before and after treatment and its clinical significance. Methods Selected 41 cases with Henoch-Schonlein purpura as the observation group and 41 cases of healthy children as control group, test CD4+CD25+CD127+ in two group. Results (1)Before treatment compared with control group, CD4+CD25+CD127+ significantly lower (P ＜ 0.05); (2)Before treatment and observation groups, the observation group of children with CD4+CD25+CD127+ the value was significantly higher after treatment (P ＞ 0.05); (3)Compared with the control group， study group patients after treatment CD4+CD25+CD127+ value of the difference was not statistically significant (P ＞ 0.05). Conclusion Peripheral blood CD4+CD25+CD127+ value in the treatment of children with Henoch-Schonlein purpura were significantly reduced, giving an effective treatment significantly increased its value, may be allergic purpura development of the disease process of regulatory T cells were involved. For children with Henoch-Schonlein purpura predict the disease, can their CD4+CD25+ CD127+ v