奥替溴铵对肠易激综合征患者IL-18及TNF-α影响.doc

奥替溴铵对肠易激综合征患者IL-18及TNF-α影响[摘要] 目的 观察奥替溴铵联合双歧杆菌三联活菌胶囊治疗肠易激综合征的疗效及对血清中IL-18和TNF-α的影响。方法 收集190例患者，依入院顺序分为观察组（95例）与对照组（95例），对照组患者应用蒙脱石散、双歧杆菌三联活菌胶囊进行治疗，观察组应用蒙脱石散、奥替溴铵、双歧杆菌三联活菌胶囊进行治疗。结果 治疗后观察组治疗的显效率明显高于对照组患者，二组治疗后血清中IL-18和TNF-α均下降，但是观察组的下降值更明显。 结论 奥替溴铵联合双歧杆菌三联活菌胶囊治疗肠易激综合征的效果明显，并能有效调节血清中IL-18和TNF-α的含量，临床治疗中可以积极应用。 [关键词] 白细胞介素-18；肿瘤坏死因子-α；奥替溴铵；双歧杆菌三联活菌胶囊；肠易激综合症 [中图分类号] R969.4 [文献标识码] B [文章编号] 1673-9701（2011）36-40-02 The Effect of Otlonium Bromide on Expression of IL-18 and TNF-α in Patients with Irritable Bowel Syndrome ZHONG Yufen YAN Haifan CHEN Zhenhua The First People’s Hospital of Wenling City, Wenling 317500, China [Abstract] Objective To observe the curative effect, IL-18 and TNF-α change by otlonium bromide and bifid-triple viable capsule in patients with irritable bowel syndrome. Methods All 190 patients with irrtable bowel syndrome were divided into two groups. The control group (95 cases) were treated by Meichangan and bifid-triple viable capsule treatment, the observation group (95 cases) were treated by Meichangan, otlonium bromide and bifid-triple viable capsule. Results The obvious effective rate was obviously higher in the observation group than in the control group. The change value of IL-18 and TNF-α were obviously higher in the observation group after treatment. Conclusion The treatment of Meichangan, otlonium bromide and bifid-triple viable capsule can improve the curative effect, regulate the expressions of IL-18 and TNF-α in patients with irritable bowel syndroe, is worthy be recommended in clinical treatment. [Key words] IL-18; TNF-α; Otlonium bromide; Bifid-triple viable capsule; Irritable bowel syndrome 肠易激综合征是一种常见的以腹痛、腹部不适伴排便习惯改变为特征的功能性肠道疾病，目前其发病率高，临床表现较为复杂[1]。近来有研究显示患者血清中的炎性细胞因子表达增高[2]，白细胞介素-18（IL-18）和肿瘤坏死因子-α（TNF-α）是促炎细胞因子[3]，二者在肠易激综合征的发生发展中可能具有促进价值。奥替溴铵对于消化道平滑肌能够发挥强烈的解痉作用，而双歧杆菌三联活菌胶囊可以调整肠道菌群平衡，抑制并清除肠道中致病菌，减少肠源性毒素的产生，促进机体对营养物质的消化。本文观察奥替溴铵联合双歧杆菌三联活菌胶囊治疗肠易激综合征的临床效果，观察治疗前后血清中IL-18和TNF-α的变化，旨在为临床工作提供理论支持。 1 资料与方法 1.1 临床资