小剂量肝素治疗婴幼儿重症肺炎临床探究.doc

小剂量肝素治疗婴幼儿重症肺炎临床探究[摘要] 目的 探讨小剂量肝素治疗婴幼儿重症肺炎的临床效果。方法 选择2006年8月～2007年9月在我科住院治疗的60例重症肺炎患儿，随机分为观察组和对照组，对照组采用常规治疗，观察组在常规治疗的基础上加用小剂量肝素，比较两组疗效、症状改善和副作用。结果 观察组的治疗总有效率为93.3%，对照组为70.0%（21/30），差异有统计学意义（P＜0.05）；观察组喘平消失时间、紫绀消失时间、?音消失时间和住院时间均要短于对照组，两组比较差异有统计学意义（P＜0.05）；治疗组副作用发生率为6.7%，对照组为33.3%，差异有统计学意义（P＜0.05）。结论 辅助用小剂量肝素治疗婴幼儿重症肺炎具有较好的疗效，值得在临床推广使用。 [关键词] 肝素；小剂量；重症肺炎；婴幼儿 [中图分类号] R563.1 [文献标识码] A [文章编号] 1673-9701（2009）12-23-02 Clinical Research of Micro-dosage Heparin in Treatment of Neonatal Severe Pneumonia QIN Jiaona1YU Qing2HU Qingxu3WANGTieyan1WANG Xinhua1ZHAO Jia1ZHANG Yi1PANG Fengwei1CHEN Liying1 1.The Second Hospital of Qiqihar；2.MCH Hospital of Qiqihar；3.Jianhua Factory Hospital of Qiqihar，Heilongjiang 161000 [Abstract] Objective To explore the clinical effect of micro-dosage heparin in treatment of neonatal severe pneumonia. Methods 60 infants with severe pneumonia were selected in our departmentfrom Aug 2006 to Sep 2007，who were divided into observation group and control group，the control group were treated with traditional method，the observation group were added micro-dosage heparin. Their clinical effect，symptom improvement and side effect were compared. Results The total effect of the observation group was 93.3%，the control group was 70%，the difference had statistical significance（P＜0.05）；the chuan ping disappear time，cyanosis disappear time，ralc disappear time and hospital time of the observation group are shorter than the control group， the difference statistical significant（P＜0.05）；the side effect rate of the observation group was 6.7%， the control group was 33.3%，the difference had statistical significant（P＜0.05）. Conclusion It has good effect by using micro-dosage heparin to treat neonatal severe pneumonia and is valued to widely used in clinic. [Key Words] Heparin；Micro-dosage；Severe pneumonia；Infants 肺炎是由于不同病原体或不同因素所致的肺部炎症，是常见的下呼吸道感染，而婴幼儿患重症肺炎时机体明显缺氧、酸碱平衡失调、电解质紊乱，病情变化快，是5岁以下小儿的重要死亡原因，临床上一直都很重视抗感染的治疗，但是如果感染后的抗炎及其他辅助治疗措施不得力，常可出现急性肺损伤、多器官功能不