红金消结胶囊对子宫内膜异位症影响.docVIP

红金消结胶囊对子宫内膜异位症影响【摘要】目的:观察异位内膜体积及ER、PR的含量,探讨红金消结胶囊对子宫内膜异位症的影响。方法:雌性健康Wistar大鼠50只,随机选取10只大鼠作为正常对照组,其余制备子宫内膜异位症(EMT)模型,EMT术后饲养4周,随机分为4组,即模型对照组、达那唑组、红金消结胶囊大剂量组、红金消结胶囊小剂量组,每组均为10只。各组均于造模后第29天给药,其中红金消结胶囊大、小剂量组分别按300 mg/kg、150 mg/kg 给药,达那唑组以100 mg/kg 给药,正常对照组与模型对照组给生理盐水,灌胃,每日1 次,连续给药8周。观察比较四组异位内膜体积变化及E2、ER的含量变化。结果:给药后大鼠腹腔异位的子宫内膜体积变化,红金消结胶囊大、小剂量组异位内膜体积大于模型对照组,差异有显著性(P?0.05),而且大剂量组体积较小剂量组体积小(P?0.05);模型组大鼠血清E2和异位内膜ER水平显著高于正常对照组(P0. 01),经达那唑、红金消结胶囊治疗后均有不同程度的降低,其中达那唑和红金消结胶囊高剂量组与模型组比其差异有极显著意义(P 0. 01),小剂量组其差异有显著性(P 0.05)。结论:红金消结胶囊能有抑制大鼠异位内膜的生长,降低血清E2和异位内膜ER水平,对子宫内膜异位症有确切疗效。 【关键词】红金消结胶囊;子宫内膜异位症 Influence of Hong-jin Xiao-jie Capsule to endometriosis in rats Duan Yan-Jie(Second Affiliated Hospital of Chinese PLA General Hospital, Beijing, 100091)? 【Abstract】 Objective:To observe the influence of Hong-jin Xiao-jie Capsule to endometriosis.Methods:Ten female heathy Wistar rats were selected at random as control group. Forty endometriosis ratmodels were made.Twenty-nine days after operation,EMS model rats were randomly divided into 4 groups: a model group,a danazol group, a high-dose Hong-jin Xiao-jie Capsule group and a low- dose Hong-jin Xiao-jie Capsule group . All the rats were treatedfor eight weeks respectively, and then anaesthetised and killed. The ectopic endometrium?s volume , ER and serum E2 were measured and compared. Results:The ectopic endometrium?s volume in high-dose and low-dose larger than that in model group,significantly(P?0.05),and the volume in low-dose group was larger than that in high-dose group(P?0.05). The serum E2 and ER in ectopic endometriums in model group were higer than control group(P0. 01), danazol group(P 0. 01),high-dose Hong-jin Xiao-jie Capsule group(P 0. 01),and low- dose Hong-jin Xiao-jie Capsule group(P 0.05).. Conclusion:Hong-jin Xiao-jie Capsule inhibited growth of the ectopic endometriums,lowered serum E2 and ER in ectopic endometriums,and showed a significant therapeutic effects on EMSmodel rat. 【Keywords】Hong-jin Xiao-j