托莫西汀和阿立哌唑治疗儿童注意缺陷多动障碍的疗效比较.pdf

现代药物与临床 Drugs Clinic 第 32 卷 第 2 期 2017 年 2 月 ·245 · 托莫西汀和阿立哌唑治疗儿童注意缺陷多动障碍的疗效比较 姜 琳 大连市第七人民医院，辽宁 大连 116023 摘 要：目的 比较托莫西汀和阿立哌唑治疗儿童注意缺陷多动障碍的临床疗效。方法 收集 2015 年 1 月—2016 年 1 月在 大连市第七人民医院诊治的 88 例注意缺陷多动障碍患者，根据用药方案的不同分为对照组和治疗组，每组各 44 例。对照组 患儿口服阿立哌唑片，1 片/次，每晚 1 次。治疗组患儿口服盐酸托莫西汀胶囊，初始剂量为每天 0.5 mg/kg，治疗过程中根 据临床反应及耐药性进行剂量调整，每天最大剂量为 1.4 mg/kg。两组患儿均连续治疗 6 周。比较两组患儿临床效果、SNAP-IV 量表评分、数字划消失误率和 Conners 父母量表测验结果。结果 治疗后，对照组和治疗组的总有效率分别为 81.82%、97.73%， 两组总有效率比较差异具有统计学意义（P ＜0.05 ）。治疗后，两组患儿 SNAP-IV 量表评分、数字划消失误率和 Conners 父母 量表测验结果均显著改善，同组治疗前后比较差异具有统计学意义（P ＜0.05 ）；且治疗后治疗组患儿上述观察指标比对照组 的改善更明显，两组比较差异有统计学意义（P ＜0.05 ）。结论 托莫西汀治疗注意缺陷多动障碍临床效果显著，有利于患者 认知功能的改善，具有一定的临床推广应用价值。 关键词：盐酸托莫西汀胶囊；阿立哌唑片；注意缺陷多动障碍；SNAP-IV 量表评分 中图分类号：R985 文献标志码：A 文章编号：1674 - 5515(2017)02 - 0245 - 04 DOI: 10.7501/j.issn.1674-5515.2017.02.020 Comparison on clinical efficacy of atomoxetine and aripiprazole in treatment of children with attention deficit hyperactivity disorder JIANG Lin Dalian Seventh Peoples Hospital, Dalian 116023, China Abstract: Objective To compare the clinical efficacy of aripiprazole and atomoxetine in treatment of children with attention deficit hyperactivity disorder. Methods Children (88 cases) with attention deficit hyperactivity disorder in Dalian Seventh Peoples Hospital from January 2015 to January 2016 were divided into control and treatment groups based on different treatments, and each group had 44 cases. Children in the control group were po administered with Aripiprazole Tablets, 1 tablet/time, once per night. Children in the treatment group were po administered with Atomoxetine Hydrochloride Capsules., The initial dosage was 0.5 mg/kg daily, and which was adjusted according to clinical response and drug resistance, and the maximum dosage was 1.4 mg/kg daily. Children in two groups were treated for 6 wee