甘氨双唑钠在早期乳腺癌保乳术加术后放疗中增敏作用临床观察.docVIP

甘氨双唑钠在早期乳腺癌保乳术加术后放疗中增敏作用临床观察[摘要]目的探讨甘氨双唑钠（CMNa）在早期乳腺癌保乳术加术后放疗中是否有增敏作用。方法2009年12月至2011年10月，对45例早期乳腺癌患者行保乳术，术后随机分为A、B两组进行放疗；A组放疗前不使用CMNa，B组放疗前使用CMNa，并按CMNa放疗增敏比减少放射剂量。手术后6～24个月随访，观察术后治疗效果、美容效果及不良反应。结果A、B两组在治疗效果、美容效果、不良反应三方面均无统计学差异。结论甘氨双唑钠在早期乳腺癌保乳术加术后放疗中确实有增敏作用，没有增加放疗的不良反应，值得在放疗领域推广使用。 关键词：甘氨双唑钠（CMNa）早期乳腺癌保乳术联合术后放疗 [Abstract]Objective: TO study whether sodiumglycididazole（CMNa）has sensitizing effect in radiotherapy after breast conserving surgery for people who have early breast cancer. Method: 45 cases with early breast carcinoma were divided into A,B two group according to the age after breast conserving surgery, and they all were given radiotherapy. A group before radiotherapy does not use CMNa，B group before radiotherapy use CMNa and B group reduced radiation dose according to SER of CMNa. After 6 to 24 months follow-up，therapeutic and beautifying effect as well as advertise effect of the treatment modality were observed. Result:A, B two group effects in therapeutic and beautifying effect as well as advertise effect of the treatment of no statistical difference. Conclusion: CMNa dose has sensitizing effect in radiotherapy after breast conserving surgery for people who have early breast cancer and dose not increase in side effects. In the end, the medicine is recommendable in radiation field. key Word：Sodium glycididazole（CMNa） Early breast cancerBreast conserving surgeryRadiotherapy 中图分类号：R730.53 文献标识码：B 文章编号：1004-7484（2011）11-0075-03 1材料与方法 1.1 病例选择 2009年12月至2011年10月，我院收治Ⅰ～Ⅱ期乳腺癌病人45例，全为女性，术前均行钼靶X线，B超及MRI检查，肿瘤最大直径4cm，均获病理证实，年龄29～68岁，中位年龄40岁，一般临床特征： General clinical characteristics of the patients included in this study Characteristics Number of patients（n） Percentage（%） Age（y） ≤35 4 8.9% 35～55 33 73.3% ＞55 8 17.8% Tum or size（diameter） d≤1cm 4 8.9% 1cm＜d≤2cm 26 57.8% 2cm＜d≤4cm 15 33.3% Number of positive nodes 0 29 64.4% 1～3 14 31.1% 4～10 2 4.5% Histological type Ductal carcinoma in situ 19 42.