睡眠剥夺对青年男性执行功能影响.docVIP

睡眠剥夺对青年男性执行功能影响【摘 要】 目的:应用事件相关脑电位(event related potential,ERP)技术探讨完全睡眠剥夺(total sleep deprivation,TSD)对大脑执行功能的影响。方法:采用被试内两因素重复测量设计。14名健康男性硕士参加2次试验,第1次作为对照,正常睡眠;第2次接受36 h睡眠剥夺。在每次试验中被试共进行5次Go/Nogo测验,同时记录事件相关脑电位N2、P3的波幅和潜伏期及行为学数据。结果:在测量时间水平上,Fz电极Nogo-N2的波幅与基线值相比,12 h后减小[(-5.21±2.62)μV vs.(- 6.66±3.19)μV]。Fz电极Nogo-P3的波幅和潜伏期与基线值相比,在24 h后波幅下降,潜伏期延长[(8.51±7.34)μV vs.(11.80± 6.70)μV;(376.36±38.68)ms vs.(364.10± 39.97)ms]。在睡眠与否水平上,睡眠剥夺时Fz电极Nogo-N2、Nogo-P3的波幅低于正常睡眠值[(-4.91±3.27)μV vs.(- 6.06±2.96)μV;(8.43±6.65)μV vs.(9.97±6.36) μV],Cz电极Nogo-P3的潜伏期长于正常睡眠值[(375.40±39.55)ms vs.(364.96± 39.17)ms]。结论:随着睡眠剥夺时间的延长,N2、P3呈现波幅逐渐减小潜伏期逐渐延长的趋势,提示睡眠剥夺可能损害大脑的执行功能。 【关键词】 睡眠剥夺;执行功能;N2;P3;事件相关脑电位;自身对照研究 中图分类号:B845.66 文献标识码:A 文章编号:1000-6729(2010)007-0541-06 doi:10.3969/j.issn.1000-6729.2010.07.省略 【Abstract】 Objective:To explore the effect of total sleep deprivation(TSD)on executive function using event related potential(ERP)technology.Methods:Fourteen healthy male college students participated in two trials.In the first trial they had a normal sleep and the results were taken as control.In the second trail they experienced 36 hours of sleep deprivation.In each trial the subjects were tested by five Go/Nogo tasks before Nogo-N2,Nogo-P3 amplitude and latency of ERP,and behavioral data were recorded.Results:As time points were concerned,the amplitude of Nogo-N2 on Fz electrode decreased after 12 h when compared to the baseline[(-5.21±2.62)μV vs.(- 6.66±3.19)μV].The amplitude and latency of Nogo-P3 on Fz electrode changed after 24h.The amplitude decreased while the latency was extended when compared to the baseline[(8.51±7.34)μV vs.(11.80± 6.70)μV;(376.36±38.68)ms vs.(364.10± 39.97)ms].In terms of sleep,the subjects experienced sleep deprivation had lower amplitude of Nogo-N2 and Nogo-P3 than their normal sleep situation[(-4.91±3.27)μV vs.(- 6.06±2.96)μV;(8.43±6.65)μV vs.(9.97±6.36)μV].The latency of Nogo-P3 on Cz electrode was longer than the normal value[(375.40±39.55)ms vs.(364.96± 39.17