鼠NGF联合钙拮抗剂对高血压性脑出血患者血肿体积神经损伤程度及实验室指标的影响.docVIP

强化神经营养方案联合钙拮抗剂对高血压性脑出血患者神经损伤程度及实验室指标的影响 【摘要】目的:探讨强化神经营养方案联合钙拮抗剂对高血压性脑出血患者神经损伤程度及实验室指标的影响。方法：研究对象选取我院2014年3月-2016年3月收治高血压性脑出血患者共120例，以随机数字表法分为对照组（60例）和观察组（60例），分别在尼莫地平基础上给予神经节苷脂钠单用和神经节苷脂钠与鼠NGF联用治疗，比较两组患者近期疗效，治疗前后血肿体积、水肿面积、NIHSS评分、SIS评分、Barthel指数评分、IL-8、TNF-α、MMP-9、MDA、SOD及MBP水平等。结果：观察组患者治疗显效率和总有效率均显著高于对照组（p0.05）；观察组患者治疗后血肿体积和水肿面积均显著小于对照组、治疗前（p0.05）；观察组患者治疗后NIHSS评分、SIS评分及Barthel指数评分均显著优于对照组、治疗前（p0.05）；观察组患者治疗后MMP-9、IL-8及TNF-α水平均显著低于对照组、治疗前（p0.05）；观察组患者治疗后MDA和SOD水平均显著低于对照组、治疗前（p0.05）；观察组患者治疗后MBP水平显著低于对照组、治疗前（p0.05）。结论：强化神经营养方案联合钙拮抗剂治疗高血压性脑出血可有效修复受损神经功能，控制血肿和水肿范围，改善日常生活质量，并有助于调节炎性细胞因子，氧化应激指标及MBP水平。 【关键词】神经节苷脂钠；鼠NGF；高血压性脑出血；疗效 Influence of intensive nerve nutrition scheme combined with calcium antagonist on the nerve injury degree and the levels of laboratory index of patients with hypertensive cerebral hemorrhage Abstract：Objective To investigate the influence of intensive nerve nutrition scheme combined with calcium antagonist on the nerve injury degree and the levels of laboratory index of patients with hypertensive cerebral hemorrhage. Methods 120 patients with hypertensive cerebral hemorrhage in the period from March 2014 to March 2016 in our hospital were chosen and randomly divided into both group including control group (60 patients) with monosialotetrahexosyl ganglioside sodium used alone and observation group (60 patients) with monosialotetrahexosyl ganglioside sodium combined with NGF on the basis of nimodipine; and the clinical effects for short-term, the hematoma volume, the edema area, the NIHSS score, the SIS scores, the Barthel index score, the levels of IL-8, TNF-α, MMP-9, MDA, SOD and MBP before and after treatment of both groups were compared. Results The clinical excellent effects and total effects for short-term of observation group were significantly higher than control group（p0.05）. The hematoma volume and the edema area after treatment of observation group were significantly less than control group and before treatment（p0.05）. The NIHSS score, the