脑胶质瘤干细胞(BGSCs)综述（A review of brain glioma stem cells (BGSCs)）.docVIP

脑胶质瘤干细胞(BGSCs)综述（A review of brain glioma stem cells (BGSCs)） Overview Brain glioma stem cells 2007 Bethune medical classHou Tingting Neural stem cells (NSCs); glioblastoma; glial cells; drug therapy It was previously thought that tumors were mutated by somatic cells, and that every tumor cell could grow without restriction. But this does not explain the seemingly limitless vitality of tumor cells and the fact that not all tumor cells can grow indefinitely. The basic characteristics of tumor cell growth, metastasis and recurrence of stem cells is very similar, therefore, some scholars put forward the cancer stem cell theory, this theory for the origin and nature of our understanding of the tumor, and the clinical treatment of tumors with direction and new visual angle. The origin of brain glioma in brain glioma stem cells (brain gliomastem cells.BGSCs) theory of the correct understanding of the genesis and development of human glioma and its biological behavior such as invasion, metastasis, tumor resistance etc has important theoretical significance and potential application value. With the development of the study, more and more scholars have isolated a small number of tumor cells which play the role of stem cells in brain glioma cells, that is, glioma stem cells. They play a decisive role in the growth and recurrence of brain gliomas. There are two general opinions about the origin of glioma stem cells: one is derived from neural stem cells, that is, undifferentiated neural stem cells derived from the nerve region. There are three theoretical bases for this view. First, the subventricular zone is the predilection area of brain glioma, and the carcinogenic rate of the subventricular zone is higher than that of other cortical areas. Two, self renewing neural stem cells have a strong mechanism, few mutations that have the potential of malignant transformation, and stem cells survive longer, which means that the error probability of stem cells for cell repli