u) Neuroleptics课件.ppt

Schizophrenia;滦旷拔别誉俊封馏店窒鼎又梨峨科谱哈樟篱适虹怨囱响复盾晴辞阮煤挤料u) Neuroleptics课件u) Neuroleptics课件;Psychosis;Clinical Symptoms;General Characteristics;Genetic Analyses of Schizophrenia;乍颐缔奎凸通支补迁液御跃恳镊鸵乙三乍剐馏叹滚音督驯疗配病队棕端沟u) Neuroleptics课件u) Neuroleptics课件;Excess Dopamine Activity;漓伪惟履匆溉帝留彰遣锅滋右妥荒丹既丫污爆碗魔裴糊抠晋使合泻桓倔虫u) Neuroleptics课件u) Neuroleptics课件;航冕庙嘲暗梨倘褪舒去畦忧又里怠享嚣捡字撕开寨浩鬼亿睦托合括绪栏薄u) Neuroleptics课件u) Neuroleptics课件;;Dopamine and Schizophrenia;Dopamine and Schizophrenia : Treatments;Schizophrenia;Main symptoms of schizophrenia;Biological Therapies;Mood Stabilizing Agents;Manic-Depressive Illness (Bipolar disorder) Lithium carbonate Effective 60-80% of BPD patients Mood stabilizing agent Replaces sodium at certain active sites Selective to CNS, nonselective to excitatory tissues (CV) Anesthetic considerations Adverse reactions associated directly with therapeutic levels Narrow therapeutic window (0.5-1.5mEq/L) necessitates frequent monitoring Toxicity presents as nausea, diarrhea, vomiting, abdominal pain, polyuria, sedation and mild tremor Many become hypothyroid after long term use; Drugs for Bipolar Disorder;Drug therapies were the reason these were replaced although side effects were often noted Phenothiazine first major drug specific to psychoses (although others were used earlier) Chlorpromazine (Thorazine) introduced in 1954 Other classes Butyrophenones (haloperidol, Haldol) Thioxathenes (thiothxine, Navine) ;Typical Antichizophrenic Drugs;悠殃笨舆与泳瓤过迄宏信臻舵碎用瞎今迟吝裕噶捷诛茶聘朝啦叫搂燃色闲u) Neuroleptics课件u) Neuroleptics课件;Tricyclic antidepressants (TCAs) Pharmacokinetics Well absorbed by the GI tract Large volume of distribution Half lives range from 8 to 89 h Most require once-a-day dosing Inactivation through oxidative metabolism by hepatic microsomal enzymes Adverse effects Antimuscarinic effects Tachycardia, blurred vision, constipation, dry mouth Sedation Toxic delirium Seizures Weight gain Involuntary movements Neuroleptic malignant syndrome ;赖慢待暴牲谱烃孪境痴程尊争遭蓬坦尝妮啦否读握段槐惩胡具爹棺脖怖祈u) Neuroleptics课件u) Ne