23届全国医药经济信息发布会-新药研发中结构优化策略-张健存课件.pptVIP

中科院广州生物医药与健康研究院 呼吸病国家重点实验室 张健存 jiancunzhang@ ;医药市场;Numbers of Drug Approved Since 1950;药物开发流程;新药 RD 的周期;先到化合物的发现;Lead Molecule;先导化合物结构优化 (1): Peptide;先导化合物结构优化 (2): TS mimetic;先导化合物结构优化 (3): Endogenous Substrate（天然底物）;Fast-Follower Approach 快速跟进策略;Fast Follower Approach Analyses;Fast Follower Strategies（策略）;Pharmacorphore and Auxophore 药效基团和辅助基团;Application of Auxophores;Application of Bioisosteres 等效基团的应用;Application of Bioisosteres;我们的研究领域;Novel Tyrosine Kinase Inhibitors as anticancer agents ;Tyrosine Kinase Inhibitors as Anticancer Agents;Tumor Genotype and TKIs;Tumor Genotype and TKIs-2