N端脑钠肽前体与急性脑梗死相关性的探讨研究.docx

N端脑钠肽前体与急性脑梗死相关性的探讨研究[摘要]目的：动态观察急性脑梗死（Acute Cerebral Infarction,ACI）患者血浆N端脑钠肽前体（N terminal pro brain natriuretic peptide,NT-proBNP）的变化并评估不同梗死面积组神经功能缺损程度及预后。方法：选择神经内科收治的急性脑梗死患者90例，根据头颅MRI结果进行分组，分别于入院24 h、治疗7d、14d时抽血化验血浆NT-proBNP并进行比较，不同梗死面积组采用美国国立卫生研究院卒中量表(the national institutes of health stroke scale，NIHSS)评价患者入院24h神经功能缺损情况并追踪预后；另选取来自本院体检中心健康体检者40例为对照组。结果：急性脑梗死患者血浆NT-proBNP水平明显高于对照组(P0.05)，入院24 h时血浆NT-proBNP水平最高，后逐渐下降，2周时最低；大面积脑梗死组血浆NT-proBNP水平明显高于中面积和小面积脑梗死组(P0.05)；不同梗死部位血浆NT-proBNP水平比较差异无统计学意义(P0.05)；大面积脑梗死患者入院24h NIHSS评分明显高于中面积和小面积脑梗死组，大面积脑梗死预后最差，中面积组次之，小面积组预后最好。结论：急性脑梗死患者血浆NT-proBNP水平发病急性期明显升高，与梗死面积有关，与梗死部位无关；病灶越大，神经功能缺损越严重，预后越差。[关键词] N端脑钠肽前体；急性脑梗死Study on the relationship between N terminal pro brain natriuretic peptide and acute cerebral infarction[Abstract]Objective:Dynamic observate plasma N terminal pro brain natriuretic peptide (N terminal pro brain natriuretic peptide ,NT-proBNP) changes of patients in acute cerebral infarction (acute cerebral infarction, ACI ) and evaluate nerve function defect degree of different infarct area group and prognosis.Methods:90 patients with acute cerebral infarction admitted to Department of neurology were grouped according to the result of the head MRI, respectively,compare the blood tests of plasma NT-proBNP at 24 hour after admission, the treatment of 7 day, and the one of 14day;According to the different area of infarction group, the National Institutes of Health Stroke Scale (the National Institutes of Health Stroke Scale, NIHSS) evaluates patients with 24hour nerve function defect and prognosis. the other selected from the health examination center of 40 patients in the control group.Results: The level of plasma NT-proBNP in patients with acute cerebral infarction was significantly higher than the control group (P0.05), plasma NT-proBNP level at 24 hour after admissionis the highest, then gradually decreased and minimumat 2 weeks; plasma the level of NT-proBNP of large area in cerebral infarction group was significan