超声造影（Ultrasound angiography）.docVIP

超声造影（Ultrasound angiography） The basic principle of these contrast agents are by changing the sound attenuation, velocity and enhanced scattering, change the basic role of sonic and between organizations, namely the absorption, reflection and refraction, so that the location of the echo signal enhancement. Ultrasound contrast agent microbubbles to ideal through small lung, heart and capillary circulation, so that the peripheral intravenous contrast can be simple, and can stably maintain its effect in acoustic imaging. It is found that low solubility and low dispersion of high molecular gas, such as fluorine gas, can increase the lifetime of microbubbles in blood and increase stability. With the development of polymer chemistry, some foreign scholars using biodegradable polymeric materials to replace the Human Albumin and other natural phospholipid substances, changing the composition of micro bubble shell, thereby avoiding the problem of acoustic effect caused by the limitation of the nature of the material itself is not stable. At present the domestic and foreign research shows that polymer microbubble ultrasound contrast agent development is the most promising, it can change the polymerization conditions the acoustic properties can be designed for a tailored for the imaging condition of contrast agent, make the particle size distribution is more concentrated, after the sound attenuation is weak and prolonged in vivo the remaining time to be used in different physiological and pathological conditions and targeted drug delivery. With microbubbles especially halothane gas ultrasound contrast agent was developed and used in clinical, ultrasound contrast imaging technology is in rapid development, from the color Doppler imaging, intermittent harmonic gray-scale ultrasonography, contrast-enhanced ultrasound imaging quality has been greatly improved, the resolution is obviously improved, and greatly reduce the the artifacts, and can display real-time perfusion. Clinical