国外医学科学数据共享政策调查及对我国的启示-图书情报工作.pdfVIP

HEREDITAS (Beijing) 2010 11 , 32(11): 1091 ―1096 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2010.01091 miRNA及其靶位点多态性的研究进展 1 2 3 3 刘利英 , 徐纪茹 , 宋土生 , 黄辰 1. , , 710061; 2. , 710061; 3. , , 710061 微RNA(microRNA, miRNA)是一类进化上保守、长度为21~23 nt 的非编码单链小RNA, 参与个体发育、 器官形成、细胞增殖、分化和细胞凋亡等生物学过程, 并在其中发挥重要的调节作用。近年来研究发现, miRNA 及其靶位点的多态将引起不同类型的疾患。文章主要从 miRNA 及其靶位点的多态类型, 以及由多态性引起的 相关疾病等方面来阐述miRNA 的最新进展。 miRNA; 基因多态性; 疾病 Progress of polymorphism in microRNA and microRNA target sites 1 2 3 3 LIU Li-Ying , XU Ji-Ru , SONG Tu-Sheng , HUANG Chen 1. Key Laboratory of Environment and Genes Related to DiseasesMinistry of Education, the Central Laboratory For Biomedical Research, Medical School , Xi’an Jiaotong University , Xi’an 710061, China; 2. Department of Immunology and Microbiology, Medical School , Xi’an Jiaotong University , Xi’an 710061, China; 3. Key Laboratory of Environment and Genes Related to DiseasesMinistry of Education, Department of Genetics and Molecular Biology, Medical School , Xi’an Jiaotong University , Xi’an 710061, China Abstract: MicroRNAs (miRNAs), which are evolutionarily well-conserved, 21- to 23-nucleotide-long, small non-coding RNAs, are widely involved in the regulation of multiple biological processes, such as development, organogenesis, cell proliferation, cell differentiation, and apoptosis. Recent studies have shown that polymorphism in miRNAs and their target sites are closely related to various diseases, such as tumor and cardiological diseases. This review introduces recent pro- gresses on polymorphism in microRNAs and their