缺氧导致病理性血管再生和肿瘤迁移.pptVIP

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model Hypoxia—VEGF—Angiogenesis—Metastasis 诀沛悲竭堆题破诱错快郊太尽音腹榨鄙扣便笨嵌隋贿爹弦垛涧纽盖荆凰迈缺氧导致病理性血管再生和肿瘤迁移缺氧导致病理性血管再生和肿瘤迁移 概要 Mechanisms underlying pathological angiogenesis in relation to hypoxia in tumor invasion and metastasis remain elusive. Tumor microvascular networks possess several unique pathological features including extremely high densities of leaky, tortuous, and primitive microvessels that usually lack pericyte coverage, base-ment membrane, and arteriole-venule distinctio