多巴胺D3 受体(D3R) 的神经科学新进展.PDFVIP

17 2 Vol. 17, No. 2 2005 4 Chinese Bulletin of Life Sciences Apr., 2005 1004-0374(2005)02-0170-06 D3 (D3R) 201203 (DA)DA D 3 (D 3 R ) D 2 D3R cAMP D3R D3R D 3 R (PD)LID D3R D3R D3R PD D 3 R971; R742.2 A Advances of dopamine D3 receptor in neurobiology HE You, JIN Guo-Zhang* (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China) Abstract: Dopamine is one of important neurotransmitters in brain, and is implicated in the regulation of motor activity, cognition process and drug abuse through different dopamine receptor subtypes. The function of dopamine D3 receptor (D3R), a member of D2-like receptors, has been elusive for a long time. New advances of D3R have been achieved in recently years. Activation of D3R results in the cell mitogenesis in function assay in vitro, and the signaling pathway is not typical cAMP signal. The D3R knock-out mice have also been generated. The results from these mice show D3R plays a secondary role in physiological condition. However, the role is switched to unique “buffer action” in the pathological condition, which is premised on the prevention of various neuropsychiatric disorders such as schizophrenia, dyskinesia induced by levodopa during Parkinson’s disease therapy and drug craving. Therefore, D3R is an important therapeutic target. The antagonists of D3R are supposed to improve schizophrenia, while the PD patients and drug abuser will benefit from the agonists of D3R. Key words: dopamine D3 receptor; signaling pathway; schizophrenia; Parkinson’s disease;