甜梦口服液联合草酸艾司西酞普兰治疗抑郁症的-天津中草药杂志社.PDFVIP

·1818 · 现代药物与临床 Drugs Clinic 第 31 卷 第 11 期 2016 年 11 月 甜梦口服液联合草酸艾司西酞普兰治疗抑郁症的疗效观察 郝剑辉，杜秀生，张 怡 天津市滨海新区塘沽安定医院，天津 300457 摘 要：目的 观察甜梦口服液联合草酸艾司西酞普兰治疗抑郁症的临床疗效。方法 选取 2014 年 1 月—2015 年 12 月在 天津市滨海新区塘沽安定医院就诊的抑郁症患者 126 例，随机分为对照组和治疗组，每组各 63 例。对照组患者口服草酸艾 司西酞普兰片，10～20 mg/d 。治疗组在对照组的基础上口服甜梦口服液，40 mL/d 。两组患者均连续治疗 8 周。比较两组患 者治疗前后临床疗效、HAMD 评分和睡眠质量变化。结果 治疗后，对照组和治疗组痊愈率分别为 55.5%和 68.2%，两组比 较差异具有统计学意义（P ＜0.05 ）。治疗 2 、4 、8 周后，两组患者 HAMD 评分均明显下降，同组治疗前后比较差异具有统 计学意义（P ＜0.05 ）。且治疗2 周后治疗组HAMD 评分比对照组明显降低，两组比较差异具有统计学意义（P ＜0.05 ）。治疗后， 对照组睡眠质量改善总有效率为 87.3%，显著低于治疗组的 93.6%，两组睡眠质量改善总有效率比较差异具有统计学意义（P ＜ 0.05 ）。结论 甜梦口服液联合草酸艾司西酞普兰能够改善抑郁症患者的睡眠质量，降低不良反应，提高患者的生活质量。 关键词：甜梦口服液；草酸艾司西酞普兰片；抑郁症；HAMD 评分；睡眠质量 中图分类号：R977 文献标志码：A 文章编号：1674 - 5515(2016)11 - 1818 - 04 DOI: 10.7501/j.issn.1674-5515.2016.11.031 Clinical observation of Tianmeng Oral Liquid combined with escitalopram oxalate in treatment of depression HAO Jian-hui, DU Xiu-sheng, ZHANG Yi Tanggu Anding Hospital of Tianjin Binhai New Area, Tianjin 300457, China Abstract: Objective To observe the clinical efficacy of Tianmeng Oral Liquid combined with escitalopram oxalate in treatment of depression. Methods Patients (126 cases) with depression in Tanggu Anding Hospital of Tianjin Binhai New Area from January 2014 to December 2015 were randomly divided into the control and treatment groups, and each group had 63 cases. The patients in the control group were po administered with Escitalopram Oxalate Tablets, 10 — 20 mg/d. The patients in the treatment group were po administered with Tianmeng Oral Liquid on the basis of the control group, 40 mL/d. The patients in two groups were treated for 8 weeks. After treatment, the changes of clinical efficacies, HAMD scores, and sleep quality in two groups were compared. Results After treatment, the cure rate in the control and treatment groups were 55.5% and 68.2%, respe