肝硬化失代偿的家族性发病的状况调查-第三军医大学学报.docVIP

肝硬化失代偿的家族性发病的状况调查 赵义名 第三军医大学西南医院消化科 重庆 400038 彭贵勇，第三军医大学西南医院消化科，重庆 400038 房殿春 第三军医大学西南医院消化科，重庆 400038 　【摘要】 目的 通过肝硬化失代偿的家族性发病的状况调查，了解西南地区肝病家族史与肝炎后肝硬化的发病情况，来改善对疾病的管理,从而降低发病率和死亡率。方法 以西南医院1995-2005年病历记录资料为研究对象，所有调查数据均编码输入数据库，经过导入Microsoft Excel，用 SAS 8.0 软件进行统计学处理。结果 西南医院4000份病历中共筛选到肝硬化病例3400例,其中有家族史的患者526例，占总数的15.47%，I、II、III级亲属及无血缘关系共同生活亲属的患者占有肝病家族史的人数分别为496、8、2、20例，有血缘关系并有共同生活史的LC患病率明显高于无血缘但有共同生活史的LC患病率，共同生活的I级亲属的肝硬化的患病率较高，但家族低危险度的水平较高。结论 西南地区的家族性发病率高于国内平均水平，应加强肝炎知识的普及，加强对肝炎的控制，定期查体，避免家族内部的交叉传染，对已确诊的肝炎患者要进行积极治疗。 【关键词】肝硬化；遗传因素；家族性；调查； The survey of the incidence of familial decompensated cirrhosis 【Abstract】objective: By the investigation of the incidence of familial decompensated cirrhosis, we can learn about family history for liver disease and incidence of cirrhosis with hepatitis in southwest area in order to improve disease management and reduce morbidity and mortality. Methods: The data of Southwest Hospital from 1995 to 2005 has been collected for the study. All survey data were encoded into the database, through the import with Microsoft Excel,. SAS 8.0 software were used for statistical analysis. Results: 4000 cases of Southwest Hospital medical records were screened to 3400 cases with liver cirrhosis, including 526 cases of patients with family history, accounting for 15.47%. I, II, III degree relatives and unrelated family members living together were 496, 8, 2, 20 people respectively. Relatives who lived together presented significantly higher morbidity than the non-relatives but the prevalence of common life history. I-level relatives living together show highest morbidity among all the subgroups, but the proportion of low risk level family was high. Conclusion: The onset of southwest family was higher than national average level, and we should put more effects in the spread of the knowledge about hepatitis, strengthen the control of hepatitis, regular physical examination, to avoid cross-infection within the family in case that the family member h