解毒通脉胶囊治疗UA临床观察及对血浆PAPP-A、Hcy影响.pdfVIP

中文摘要 目的：观察解毒通脉胶囊对冠心病不稳定型心绞痛患者临床疗效及对血浆 Hcy、 PAPP-A 水平的影响，探讨解毒通脉胶囊治疗冠心病不稳定型心绞痛热毒痰瘀 证的作用机制。 方法：将住院UA 热毒痰瘀证患者64 例，随机分为两组，治疗组口服西药和解毒通脉 胶囊，对照组口服西药，两组均四周为一疗程，共服一疗程，治疗前后各查一 次Hcy、PAPP-A 含量，记录心电图改变。 结果：1．两组在心绞痛疗效上有显著性差异（p＜0.05）,可以认为治疗组在心绞痛 疗效方面优于对照组。 2．两组治疗后中医证候疗效比较有显著性差异（p＜0.05),可以认为治疗组在 中医证候疗效方面优于对照组。 3．两组在心电图疗效上无显著性差异（p＞0.05）,不能认为治疗组在心电图 疗效方面优于对照组。 4．两组在硝酸甘油停减率上有显著性差异（p＜0.05）,可以认为治疗组在硝 酸甘油停减率方面优于对照组。 5．两组治疗后Hcy 较治疗前明显降低（p＜0.05）；治疗组治疗后Hcy 较对照 组明显降低,有显著性差异（p＜0.05）。 6．两组治疗后PAPP-A 较治疗前明显降低（p＜0.05）；治疗组治疗后PAPP-A 较对照组明显降低,有显著性差异（p＜0.05）。 结论：解毒通脉胶囊无明显毒副作用，安全可靠，可以明显改善冠心病不稳定型心绞 痛热毒痰瘀证患者临床症状，降低血中Hcy、PAPP-A 含量，改善心肌供血，提 高患者生活质量，是治疗不稳定型心绞痛安全有效的药物。 关键词： 不稳定型心绞痛；解毒通脉胶囊；同型半胱氨酸；妊娠相关血浆蛋白A 。 Effects of JDTM capsules on clinical treatment and blood plasma Hcy and PAPP-A in patients with UA Abstract Objective :Observing the curative effect of the traditional Chinese herb medicine JDTM(JieDuTongMai)capsules on the disease of UA (unstable angina） and levels of blood plasma Hcy and PAPP-A , probing the mechanism of JDTM capsules in the UA patients. Methods:64 Patients of UA coming from the inpatient department were divided randomly into two groups: the control group(only treated with Western medicine)and the treatment group(treated with Western medicine and JDTM capsules). The treatment time was composed of 4 weeks. Making measurements of Hcy and PAPP-A in the blood plasma and recording changes of ECG before and after the treatment. Results: 1.Angina treatment effect in the two groups , there was significant difference (p 0.05), that the treating group effect is better than the control group. 2.After treatment, treating effectiveness of symptoms of TCM in the two groups, there was significant difference (p 0.05), that