ALDH2基因多态性与中国人缺血性脑卒中关系的Meta分析.PDFVIP

• 72 • CHINESE JOURNAL OF EVIDENCE-BASED MEDICINE, Jan. 2017, Vol. 17, No.1 ·论著·二次研究· ALDH2 基因多态性与中国人缺血性 脑卒中关系的 Meta 分析 戴蕙旭，何俏，时景璞 中国医科大学附属第一医院临床流行病学教研室（沈阳  110001 ） 【摘要】   目的    系统评价 ALDH 2 基因多态性与缺血性脑卒中的关系。方法    计算机检索 Web of Science、 PubMed、CNKI、CBM 和 WanFang Data 数据库，搜集 ALDH 2 基因多态性与缺血性脑卒中相关性的病例-对照研 究，检索时限从建库至 2016 年 10 月。由 2 名研究者分别独立按照纳入与排除标准筛选文献、提取资料并评价纳 入研究的偏倚风险后，采用 Stata 12.0 软件进行数据分析。结果    共纳入 7 个病例-对照研究，Meta 分析结果显示 ALDH 2 A 等位基因及 AA 基因型与中国人缺血性脑卒中患病相关 [A vs. G ：OR=1.430 ，95%CI （1.006，2.033 ）， P =0.046 ；AA vs. AG+GG ：OR=1.734 ，95%CI （1.267，2.373 ），P =0.001 ；AA vs. GG ：OR=1.757 ，95%CI （1.274， 2.424 ），P=0.001]。结论    ALDH 2 基因多态性与中国人缺血性脑卒中有关，A 等位基因是其潜在危险因素。 【关键词】  ALDH2 ；基因多态性；缺血性脑卒中；Meta分析 Genetic polymorphism in ALDH2 and risk of Chinese people with ischemic stroke: a meta-analysis DAI Huixu, HE Qiao, SHI Jingpu Department of Clinical Epidemiology, the First Affiliated Hospital, China Medical University, Shenyang, 110001, P.R.China Corresponding author: SHI Jingpu, Email: sjp562013@126.com 【Abstract 】 Objective    To systematically review the association between ALDH2 polymorphism and ischemic stroke. Methods    Web of Science, PubMed, CNKI, CBM and WanFang data were searched to collect case-control studies about the association between ALDH2 polymorphism and ischemic stroke from the inception to October 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta- analysis was performed by using Stata 12.0 software. Results    A total of seven case-control studies were included. The results of meta-analysis showed that the A allele and AA genotype in ALDH2 was associated with the risk of ischemic stroke (A vs. G: OR=1.430, 95%CI 1.006 to 2.033, P=0.046; AA vs. AG+GG: OR=1.734, 95%CI 1.267 to 2.373, P=0.001; AA vs. GG: OR=1.757, 95%CI 1.274 to 2.424, P=0.001). Conclusion    ALDH2 gene polymorphism may re