ACE在皮肤组织损伤修复及再生中作用探究.docVIP

ACE在皮肤组织损伤修复及再生中作用探究[摘要]血管紧张素转化酶(angiotensin-converting enzyme, ACE)是肾素-血管紧张素系统(renin-angiotensin system, RAS)激活过程中的关键性限速酶之一,可催化血管紧张素Ⅰ水解生成RAS最重要的活性产物血管紧张素Ⅱ。ACE也可使具有扩张血管反应的缓激肽生成苯丙-精二肽,还可直接作用于肾上腺皮质促进醛固酮分泌。近年来发现ACE除了降解血管紧张素I和缓激肽外,还能降解其它产物如:β-内啡肽、P物质、Ac-SDPK等。同时,ACE和中性内肽酶(neutral endopeptidase,NEP)作为终止皮肤神经-内分泌介质作用的关键酶可调控皮肤细胞的存活、创伤愈合和组织再生。本文主要阐述近年来有关ACE及其底物在皮肤组织损伤修复与再生中作用的相关研究。 [关键词]血管紧张素转化酶;创伤愈合;缓激肽;P物质;内啡肽 [中图分类号]Q813.1[文献标识码]A[文章编号]1008-6455(2010)08-1256-03 Potential role of angiotensin-converting enzyme in wound repair and regeneration LI Sheng-hong1,LIU Hong-wei1,CHENG Biao2 (1.The First Affiliated Hospital of Jinan University,Key Laboratory for Regenerative Medicine,Ministry of Education,Guangzhou 510630,Guangdong,China; 2.Department of Plastic Surgery,Guangzhou General Hospital of PLA,Guangzhou 510010,Guangdong,China) Abstract: Angiotensin-converting enzyme (ACE) is a key component of renin-angiotensin system (RAS).It converts angiotensin I (Ang I) into angiotensin II (Ang II), a pluripotent signaling peptide.In contrast to renin, another key enzyme of RAS, ACE is more promiscuous in its substrate specificity.Angiotensin I and bradykinin are well-known physiological substrates, whereas ACE also cleaves substance P,AcSDKP,β-endorphins,and several other peptides.Perhaps because of this variety of substrates,ACE affects many physiological processes including blood pressure, hematopoiesis,and fertility.Recently,a large number of studies have revealed that ACE is involved in skin function.ACE appears to be a critical regulator in controlling cutaneous inflammatory response,as well as affecting pigmentation,cell survival and tissue regeneration.Emerging evidence has suggested that ACE plays a role in the context of stem cell regulation.This review mainly summarized the evidences for the potential role of angiotensin-converting enzyme in wound repair and regeneration. Key words: angiotensin-converting enzyme;wound healing;bradykinin;substance P;endor