北虫草提取物延缓皮肤衰老实验探究.docVIP

北虫草提取物延缓皮肤衰老实验探究[摘要]目的：研究北虫草提取物对延缓D-半乳糖所致小鼠皮肤组织衰老的作用。方法：昆明种3月龄小鼠72只，雌雄各半，随机分为高剂量组、中剂量组、低剂量组、模型对照组、正常对照组和阳性对照组。各给药组、模型组和阳性组每日颈背部皮下注射D-半乳糖，连续注射42天造成亚急性衰老模型，正常组注射相同剂量生理盐水。各给药组造模的同时皮肤涂布给药，42天后取背部皮肤检测。结果：北虫草提取物能够增加衰老小鼠的含水量和SOD活力，降低皮肤中MDA含量。结论：北虫草提取物具有延缓皮肤衰老的作用。 [关键词]北虫草提取物；延缓；皮肤衰老；动物实验 [中图分类号]R332[文献标识码]A[文章编号]1008-6455（2011）04-0612-03 Experimental study on anti-skin-aging action of Cordyceps extract HUANG Guo-xin,YAN Qin-hui,ZHANG Zhong-min,LV Zai-kun,REN Wei,SU Zi-ren,ZHAO Xue-jun （RD Center of Herbal Cosmetics,Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China） Abstract:ObjectiveWeresearched the role to delay aging whichtake in the skin of mice duing to D-galactose about the extractive of Cordyeps militaris.Methods72 healthy Kunming mice of three months were randomly divided into 6 groups-control group, high dose group, middle dose group, low dose group, model control group,normal control group and positive control group. Daily giving subcutaneous injection of D-galactose on the nape back for 42 days to make the subacute senile mouse model at each medical group, model group and positive group,normal control group gave the same doses of normal saline water injection. At the same time,each medical group were coated for medicine on the skin,and we getted the unhairing skin on back to determination after 42 days.ResultsThe extractive ofCordyepsmilitariscan remarkably improve skin water contents and SOD activity, and decrease significantly MDA content. ConclusionThe extractive ofCordyepsmilitaris can delay skin aging. Key words： extractive of Cordyeps militaris; delay ;skin aging; animal experiments 随着人们对延缓皮肤衰老的关注，各种预防和延缓皮肤衰老的有效途径和方法不断被提出和总结。中草药因其独特机理和优良的美容效果现已被广泛应用于各类抗衰老的产品中。 北虫草[Cordyceps militaris(L.)Link]，又称北冬虫夏草、蛹虫草，为子囊菌亚门核菌纲球壳目麦角菌科虫草属，与冬虫夏草同属异种。《中华药海》记载：“蛹草，性味甘、平，入肺、肾二经。” 《全国中草药汇编》记载：“蛹虫草(北虫草)的子实体及蛹体也可作为冬虫夏草入药。”北虫草中含有虫草素、虫草酸、虫草多糖以及丰富的蛋白质、18种氨基酸、17种微量元素、12种维生素等营养物质，其中维生素A、B1、B2、B6、B12、C、D、E等含量高于菇类。目前，口服北虫草已被证实有良好的滋肺补肾、