早产儿青春期智力水平病例对照研究.docVIP

早产儿青春期智力水平病例对照研究【摘要】 目的 了解早产对青春期学生智力发育的影响，为采取相应的干预措施提供依据。方法 以问卷调查的方式对蚌埠市4所中学的初一和初二年级学生3 559名进行筛查，共筛查出早产儿257名。根据父母知情同意的原则，确定99例早产儿为病例组；再按同性别、同年级、同年龄（相差不超过0.5岁）、父母文化程度和职业相似及父母知情同意的原则，选取99名足月产儿为对照组。采用中国韦氏儿童智力量表（C-WISC）进行智力测试。结果 早产儿在初中阶段的言语智商、操作智商和总智商分别为106.39±13.27，105.34±14.16，?1 056.56±13.70，对照组分别为112.06±13.23，112.48±16.19，113.71±14.28，早产儿显著低于足月产儿(P值均＜0.01)。结论 早产对智力发育的不利影响会持续到青春期，社会和家庭应积极采取措施预防早产的发生。 【关键词】 智力；病例对照研究；学生；早产；青春期 【中图分类号】 R 179 B 848.5 R 722.6 【文献标识码】 A 【文章编号】 1000－9817(2007)05－0440－02 Intelligence Development of Preterm Infants in Adolescence/YAO Rong?ying?*, ZHUANG Ying, LI Hong?ying, et al. ?* Department of Preventive Medicine, Bengbu Medical College(233030), Anhui Province, China 【Abstract】 Objective To examine the influence of preterm on intelligence development of adolescents, and to provide bases for the intervention measures.Methods The suvey was conducted among 3 559 students of grade 7 and 8 in 4 junior middle schools with a self?designed questionnaire completed by parents. There were 257 children born preterm. After getting their parents’ consent, 99 children born preterm were selected and 99 controls were matched according to the same sex, grade, and age (the discrepancy less than 0.5 year) and similar educational background and occupations od parents to the cases. The intelligence quotients(IQ) of subjects were assessed with C-WISC. Results Students born preterm scored 106.39±13.27, 105.34±14.16 and 106.56±13.70 in the VIQ, PIQ and FIQ , while the controls scored 112.06±13.23, 112.48±16.19 and 113.71±14.28 respectively(?P?＜0.01). Conclusion The influences of premature birth on the intelligence can persist into adolescence. The social and family should take positive measures to prevent premature dlivery. 【Key words】 Intelligence;Case?control studies;Students;Premature birth;Puberty 随着现代医学技术的发展，早产儿的存活率不断提高。早产儿因提前娩出，神经系统在胎儿期的生长发育被干扰。脑发育与功能成熟是认知发育的物质基础，有关早产相关的脑损伤对远期智力发育的影响，国外的报道较多[1-4]，国内多限于研究早产儿在幼年和童年期心理行为发育状况及其影响因素[5-7]。为了解早产对