多种吸附剂对血浆胆红素和细胞因子吸附性能比较：新型生物材料的体外筛选实验.pdfVIP

中国组织工程研究与临床康复 匆‘，2孝匆 ，筋r 2008—01～01出版 Bdsic d ne Journal ofClinical Rehabilitative Essue Engineering Research Janua~，．2008 Vol 12．No， Adsorptive property of novel chitosan miCrOSphereS for plasma bilirubin and cytokines：A preliminary screening in vitro of noveI biomaterials* Qu Juan’，Li Ting-hong ，Zhang Jing ，Lu Wei4，Zhang Zheng．pu。 Abstract Tian11n BACKGR0UND：The effective therapy of artificial liver for severe hepatitis needs an absorbing material which possesses Universitv strong adsorptive property，high adsorption rate and good blood compatibility． 3oo070 Tianjin OBJECTIVE：To study the adsorptive property of eight novel adsorbents for plasma bilirubin and cytokines in severe Cen盯a1 hepatitis patients． Tianjin 300170， DESlGN：A controlled observation． China： ’[nstitute of Polymer Chemistry， SETTlNGS：Graduate School of Tianjin Medical University，Tianjin Haihe Hospital，Tianjin Third Central Hospital and the Nankal University， Institute of Polymer Chemistry in Nankai University． Tianjin 300071， PARTlClPANTS：Al1 plasma was collected from 30 severe hepatitis patients hospitalized in Tianjin Third Central Hospital China； Tianjin Haihe from November 2004 to November 2005．Informed consent was obtained from each patients．This experiment was approved Hospital， Tianjin by the hospital ethical commiaee．Al1 the patients were divided into two groups at random：group l r =l O1 and group 2 300350，China； the present address js the f =2O1．The level of total bilirubin fTBiL)before therapy jn two groups was(377．3±l47．5)u mol／L and(327．6± University of Tianjln 1 40，1)u mol／L，respectively． Science and METHODS： Adsorbents：Chitosan(Qingdao Lizhong Chitosan Factory，