非清髓性外周血造血干细胞移植治疗重型β-地中海贫血1例.pdfVIP

中国组织上程研究与临床康复 第，2眷 3崩 2008一Ol—l5出版 Journal ofClinical Rehabilitative Tissue Engineering Research January 15,2008 Vol 12，No．3 非清髓性外周血造血干细胞移植治疗重型13．地中海贫血1例木☆ 朱志刚，李庆山，王汉平，王顺清，毛 平 Nonmyeloablation allogeneic peripheral blood hematopoietic stem cell transplantation for beta-thalassemia majorinone case Zhu Zhi·gang，Li Qing—shan，Wang Han·ping，Wang Shun-qing，Mao Ping Abstract AⅡ ：Allogeneic hematopoietic stem cell transplantation is the only method to treat B．thalassemia maior．This study was Department of aimed to observe the efficacy and complication of peripheral blood hematopoietic stem celltransplantation witI1 Haematology， Guangzhou First nonmyeloablation based on fluadarabine and antithymocyte globulin for B．thalassemia major． People’s Hospital， METH0DS：An eleven．year old patient was admired at Department of Haematology．Guangzhou First People’s Hospital in Guangzhou November 2002．The patient was diagnosed as having homozygote B—thalassemia major when birth．The patient and family 5 10180， Guangdong members signed the informed consent and山e experiment was approved by hospital ethics committee．Allogeneic peripheral Province．China blood hematopoietic stem cell transplantation was performed in the patient．The donor was his sister with heterozygote B Zhu Zhi-gang ☆ ． — thalassemia mi nor．Donor-recipient human leukocyte antigen was identicaland they had sanle red cell blood type． Studying for Conditioning regimen consisted of fluadarabine 35 mg／m per day，busulfan 4 mg／kg per day and antithymocyte globulin 200 doctorate， Associate