干细胞中的骨形态发生蛋白信号转导机制.pdfVIP

l【j 7 综述 Journal ofClinical Rehabilitative 71ssue Engineering Research January 15，2008 Vo1．12，No．3中国组织工程研究与临床康复第，2誊笫3 2008一Ol—l5出版 干细胞中的骨形态发生蛋白信号转导机StJ* 付 娜，王 捷 Bone morphogenetic protein signal transduction mechanism in stem cells Fu Na，Wang Jie Abstract center of Medical BACKGRoUND：Bone morphogenetic proteins(BMPs)，multifunctional secreted signaling molecules，are members of transforming Research，Guangzhou growth factor-B(TGF-B)superfamily．BMP could regulate embryonic morphology，organ development and germ cell differentiation Gener~ Hospital of Guangzhou Military by signal cascades．They could also induce stem cell differentiation and apoptosis．1_he signal transduction pathway of BMPs is Area Command of various in different stem cells．Although the reason remalas uncertain，some studies have suggested that it may be related with the Chinese PLA． receptor or the integration of various signals． Guangzhou oBJECTIVE：To review the role and transduction mechanism of BMP signal pathway in several stem cells． 5】0o】n Guangdong Province，China RETRIEVAL STRATEGY：Using the keywords of”bone morphogenetic protein．the differentiation and proliferation of stem cell”， we searched Pubmed database for related English articles dated between April and July 20o7．A total of 45 articles were collected． Fu Na★ ．Studying after the first trail only the articles(~related to bone morphogenetic protein signal transduction pathway and(~3ublished recently or for master’s degree, in authoritative iournal in the salne research field were selected．Repeated research and Meta analysis articles were excluded． Center of Medical LITERATURE EVALUATIoN：Most articles were analysis of BMP signal transduction．Of the 3 l selected articles，2 were review Research，Guangzhou General Hospital of articl