老年胰腺癌与糖尿病关系分析.pdfVIP

老年医学与保健2008年第l4卷第1期 Geriatr Health Care，2008，Vo1．14．NO．1 老年胰腺癌与糖尿病关系分析 张 伟 于晓峰 孙 皎 顾同进 王兴鹏 【摘要】目的 分析老年胰腺癌的临床特征，探讨老年胰腺癌与糖尿病之间的关系。方法 对2003年1月 2006年l2月华东医院老年(≥60岁)胰腺癌病例进行回顾性分析，评价胰腺癌与糖尿病的关系；对胰腺癌合并糖 尿病病例分析．评价老年胰腺癌合并糖尿病患者的临床特点及意义。结果 1．老年胰腺癌的临床表现以黄疸、消瘦、 腹胀和上腹不适为主。2．在胰腺癌组中2年内确诊糖尿病有31例(39．24％)，而对照组中有4例(5．0％)，两组比较差异 有统计学意义。胰腺癌组中糖尿病病史两年以』-有1 1例(13．92％)，对照组中有6例(7．5％)，两组差异无统计学意义 (尸0．05)。3．老年胰腺癌合并糖尿病患者罹患胰头癌比例高，且CA199阳性率高于非糖尿病患者，两者差异有统计学 意义(PO．05)。结论 糖尿病是胰腺癌的继发性的临床伴发症状，所以老年人一旦出现血糖异常波动，须警惕胰腺癌 的可能。 【关键词】胰腺肿瘤； 糖尿病； 老年人 【巾图分类号】R589 【文献标识码】A 【文章编号】 1 008—8296(2008)一0 1—0042—04 Clinical analysis of correlation between pancreatic carcinoma and diabetes mellitus in the elderly ZH NG Wei，YUXiao-reng，SUNJiao，GU Tong-7in，WANG Xin-peng Departmenr ofGastroenteroIogy，Huadong Hospital，Fudan University，Shanghai 200040，China 【Abstract】objective To observe clinical characteristics of senile pancreatic carcinoma(PC)and explore the corl‘elation between diahetes mellitus(DM)and PC in people over 60 years．Methods PC patients over 60 years were reU·ospectively reviewe(1 in HuaDong Hospital from Jan．2003 to Dec．2006．Clinical characteristics were evaluatecl in PC cases with DM．Results 1．Diahetes is commonly related with P(：in the elderly；abdominal pain、jaundice and weight—lose are the nlajor clinical manifestations．2．The incidence of diabetes within 2yr in PC group was 3 1 cases(39．24％)，and the control group was 4 ca~es(5．0％) 0．05)．Howevm clinical onset of diabetes beyond 2yl‘in PC group was 1 1(13．92％)，and the control group was 6 cases(7．5％)(， 0．05)respectively．3．More frequent oecurancc ofcarcinoma in head ofpancreas and higher CAl99 were in the elderly with diabetes f火0．05)．Conclusions Diabetes is a co—existing manifestation of PC．For old people with abnormal hlood glue·ose．a careful examination of the panclCkls is imp()rtant t