治疗慢性丙型肝炎患者合并的抑郁症状对患者生存质量和血清BDNF表达的影响.docVIP

治疗慢性丙型肝炎患者合并的抑郁症状对患者生存质量和血清BDNF表达的影响 曾 妍1，杨 健2，况 利1 （400016重庆，重庆医科大学附属第一医院心理卫生中心1；？？？2） [摘要]目的 研究治疗慢性丙型肝炎（hepatitis c virus，HCV）患者合并的抑郁症状对患者生存质量和血清人脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）表达的影响。方法 将伴发抑郁的HCV患者随机分组给予抗抑郁+抗病毒治疗或单纯抗病毒治疗，单纯HCV患者组给予单纯抗病毒治疗，与正常人群对照，分别收集治疗前和6月后的血清，ELISA法测血清BDNF水平，QOL-LD量表和HAMD量表分别评估患者生存质量和抑郁程度，并对数据进行统计学分析。结果 HCV合并抑郁患者组在治疗前后QOL-LD和HAMD量表评分变化差异有统计学意义（P？）；HCV伴抑郁组BDNF水平低于单纯HCV组患者（P？），且治疗后恢复速度更慢；HAMD量表、QOL-LD量表与血清BDNF水平呈显著负相关（r=？，P？）；治疗合并的抑郁症状后，慢性丙肝患者生存质量提高（P？）。结论 治疗慢性丙型肝炎患者合并的抑郁症状有利于改善患者的生存质量，提高患者的BDNF水平。 [关键词] HCV；抑郁；生存质量；BDNF [中国图书分类号] R512.6+3； R749.2+1 [文献类别码] A Influence of curing depressive symptoms on life quality and serum BDNF levels in patients with comorbidity of chronic hepatitis C and depression Zeng Yan1，Yang Jian2，Kuang Li1 （The First Affiliated Hospital of Chongqing Medical University， Chongqing 400016， China1；？？？2） [Abstract] Objective To investigate influence of curing depressive symptoms on life quality and serum BDNF levels in patients with comorbidity of chronic hepatitis C and depression， and provide evidence for improving treatmeant and life quality in these patients. Methods Chronic HCV patients with depression comorbidity were separately treated with antidepression and antiviral or only antidepression， while those HCV patients without depression comorbidity were treated with only antiviral， and serum was collected from all patients and their normal controls before treatment and 6 months after treatment， and their serum BDNF levels were detected by ELISA. Life quality and depression were assessed by QOL-LD and HAMD. All data were analyzed by SPSS18.0. Results Statistical significance was observed in patients scores of QOL-LD and HAMD； serum BDNF levels of chronic HCV patients with depression were lower and recovered slower after treatment as compared to those of patients without depression. QOL-LD and HAMD scores were negatively correlated with their corresponding serum BDNF levels； chronic HCV patie