clinicopathologic significance of hif-1, cxcr4, and vegf expression in colon cancer临床病理的意义hif-1、趋化因子受体cxcr4和vegf表达结肠癌.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2010, Article ID 537531, 10 pages doi:10.1155/2010/537531 Research Article Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer Yugang Wu,1, 2 Min Jin,2 Huanbai Xu,2 Zhang Shimin,2 Songbing He,3 Liang Wang,3 and Yanyun Zhang2 1 Department of Surgery, The First People Hospital of Changzhou and The Third Affi liated Hospital of Soochow University, Changzhou, Jiangsu 213000, China 2 Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, Shanghai 200025, China 3 Department of Surgery, The First Affi liated Hospital of Soochow University, Suzhou, Jiangsu 215006, China Correspondence should be addressed to Liang Wang, xiaobabyee@163.com and Yanyun Zhang, yyzhang@ Received 28 June 2010; Revised 26 August 2010; Accepted 15 September 2010 Academic Editor: Silvano Sozzani Copyright © 2010 Yugang Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We investigated the clinicopathologic significance of HIF-1, CXCR4, and VEGF expression using immumohistochemistry in human colon cancer. HIF-1, CXCR4, and VEGF high expression levels were correlated positively with TNM stage, lymph node involvement, and distant metastasis Furthermore, we found that combined high expression of any two of the three molecules (P = .028 for HIF-1/CXCR4, P = .007 for HIF-1/VEGF, and P = .004 for CXCR4/VEGF) had stronger correlation with lymph node me