cancer stem cells in head and neck squamous cell carcinoma癌症干细胞在头颈部鳞状细胞癌.pdfVIP

Hindawi Publishing Corporation Journal of Oncology Volume 2011, Article ID 762780, 8 pages doi:10.1155/2011/762780 Review Article Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma Marcus M. Monroe,1 Eric C. Anderson,2 Daniel R. Clayburgh,1 and Melissa H. Wong3 1 Department of Otolaryngology—Head and Neck Surgery, Oregon Health Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA 2 Division of Hematology and Medical Oncology, Oregon Health Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA 3 Department of Dermatology, Cell and Developmental Biology, Knight Cancer Institute, Oregon Stem Cell Center, Oregon Health Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA Correspondence should be addressed to Melissa H. Wong, wongme@ Received 31 August 2010; Accepted 1 October 2010 Academic Editor: Bo Lu Copyright © 2011 Marcus M. Monroe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (CSCs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. In head and neck squamous cell carcinoma (HNSCC), as with other malignancies, cancer stem cells have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In this paper we summarize the current knowledge of the role of CSCs in HNSCC and discu