biochemical analysis of pentraxin 3 and fibrinogen levels in experimental periodontitis model生化分析pentraxin 3和纤维蛋白原水平实验性牙周炎模型.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 809801, 7 pages doi:10.1155/2012/809801 Research Article Biochemical Analysis of Pentraxin 3 and Fibrinogen Levels in Experimental Periodontitis Model Gonca Cayir Keles,1 Umut Balli,1 Burcu Ozkan Cetinkaya,1 Bulent Ayas,2 Arzu Findik,3 Zeynep Pinar Keles,1 and Ferda Pamuk4 1 Department of Periodontology, Faculty of Dentistry, Ondokuzmayis University, 55139 Samsun, Turkey 2 Department of Histology and Embryology, Faculty of Medicine, Ondokuzmayis University, 55139 Samsun, Turkey 3 Department of Microbiology, Faculty of Veterinary Medicine, Ondokuzmayis University, 55139 Samsun, Turkey 4 Department of Periodontology, Faculty of Dentistry, Istanbul Aydin University, 34380 Istanbul, Turkey Correspondence should be addressed to Gonca Cayir Keles, goncakeles@ Received 22 March 2012; Revised 22 May 2012; Accepted 5 July 2012 Academic Editor: Hidde Bult Copyright © 2012 Gonca Cayir Keles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. Pentraxin 3 (PTX3), newly discovered inflammation marker, is a member of acute-phase proteins. The hypothesis, synthesis of gingival tissue and serum PTX-3 increases in the experimental periodontitis model (with 10-day and 40-day periods), was tested by detecting gingival tissue and serum PTX-3 levels in rats with experimental periodontitis. Methods. Thirty rats were randomly divided into three groups of ten animals each: ligature-induced experimental periodontitis groups (with 10-day (Group1) and 40-day periods (Group2)) and healthy group (Group3). At the end o