canonical source reconstruction for meg规范梅格重建来源.pdfVIP

Hindawi Publishing Corporation Computational Intelligence and Neuroscience Volume 2007, Article ID 67613, 10 pages doi:10.1155/2007/67613 Research Article Canonical Source Reconstruction for MEG ´ ´ 1 2 3 Jeremie Mattout, Richard N. Henson, and Karl J. Friston 1 INSERM U821, Dynamique Cerebrale et Cognition, Lyon, France ´ ´ 2 MRC Cognition and Brain Sciences Unit, Cambridge CB2 7EF, UK 3 The Wellcome Trust Centre for Neuroimaging, University College, London WC1N 3BG, UK ´ ´ Correspondence should be addressed to Jeremie Mattout, jeremiemattout@yahoo.fr Received 11 January 2007; Revised 24 April 2007; Accepted 27 May 2007 Recommended by Saied Sanei We describe a simple and efficient solution to the problem of reconstructing electromagnetic sources into a canonical or standard anatomical space. Its simplicity rests upon incorporating subject-specific anatomy into the forward model in a way that eschews the need for cortical surface extraction. The forward model starts with a canonical cortical mesh, defined in a standard stereotactic space. The mesh is warped, in a nonlinear fashion, to match the subject’s anatomy. This warping is the inverse of the transforma- tion derived from spatial normalization of the subject’s structural MRI image, using fully automated procedures that have been established for other imaging modalities. Electromagnetic lead fields are computed using the warped mesh, in conjunction with a spherical head model (which does not rely on individual anatomy). The ensuing forward model is inverted using an empirical Bayesian scheme that we have described previously in sev