comparison of photopic negative response of full-field and focal electroretinograms in detecting glaucomatous eyes明的负面反应的比较细致和焦视网膜电流图在检测青光眼的眼睛.pdfVIP

Hindawi Publishing Corporation Journal of Ophthalmology Volume 2011, Article ID 564131, 11 pages doi:10.1155/2011/564131 Clinical Study Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous Eyes Shigeki Machida, Kunifusa Tamada, Taku Oikawa, Yasutaka Gotoh, Tomoharu Nishimura, Muneyoshi Kaneko, and Daijiro Kurosaka Department of Ophthalmology, School of Medicine, Iwate Medical University, 19-1 Uchimaru Morioka, Iwate 020-8505, Japan Correspondence should be addressed to Shigeki Machida, smachida@iwate-med.ac.jp Received 29 April 2010; Revised 24 June 2010; Accepted 22 August 2010 Academic Editor: Christopher Leung Copyright © 2011 Shigeki Machida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. To compare the photopic negative response (PhNR) of the full-field electroretinogram (ERG) to the PhNR of the focal ERGs in detecting glaucoma. Methods. One hundred and three eyes with glaucoma and 42 normal eyes were studied. Full-field ERGs were elicited by red stimuli on a blue background. The focal ERGs were elicited by a 15◦ white stimulus spot centered on the macula, the superotemporal or the inferotemporal areas of the macula. Results. In early glaucoma, the areas under the receiver operating characteristic curves (AUCs) were significantly larger for the focal PhNR (0.863–0.924) than those for the full-field PhNR (0.666–0.748) (P .05). The sensitivity was significantly higher for the focal PhNR than for the full-field PhNR in early (P .01) and intermediate glaucoma (P .05). In advanced glaucoma, there was no difference in the