gene by sex interaction for measures of obesity in the framingham heart study肥胖基因性互动的措施在弗雷明汉心脏研究.pdfVIP

Hindawi Publishing Corporation Journal of Obesity Volume 2011, Article ID 329038, 8 pages doi:10.1155/2011/329038 Research Article Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study Ashlee M. Benjamin,1 Sunil Suchindran,1 Kaela Pearce,1 Jennifer Rowell,2 Lillian F. Lien,2 John R. Guyton,2 and Jeanette J. McCarthy1, 3 1 Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA 2 Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA 3 Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA Correspondence should be addressed to Jeanette J. McCarthy, jeanette.mccarthy@ Received 14 September 2010; Revised 17 November 2010; Accepted 22 November 2010 Academic Editor: Yvon Chagnon Copyright © 2011 Ashlee M. Benjamin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P -values .00186 to .00010) across